Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems

Ben Jiwon Choi, Yu Chieh David Chen, Claude Desplan

Research output: Contribution to journalReview articlepeer-review

Abstract

During the development of the vertebrate nervous systems, genetic programs assemble an immature circuit that is subsequently refined by neuronal activity evoked by external stimuli. However, prior to sensory experience, the intrinsic property of the developing nervous system also triggers correlated network-level neuronal activity, with retinal waves in the developing vertebrate retina being the best documented example. Spontaneous activity has also been found in the visual system of Drosophila. Here, we compare the spontaneous activity of the developing visual systembetween mammalian and Drosophila and suggest that Drosophila is an emerging model for mechanistic and functional studies of correlated spontaneous activity.

Original languageEnglish (US)
Pages (from-to)677-691
Number of pages15
JournalGenes and Development
Volume35
Issue number9-10
DOIs
StatePublished - May 1 2021

Keywords

  • Drosophila
  • Gap junctions
  • Neural development
  • Spontaneous activity
  • Vertebrates versus invertebrates
  • Visual system
  • Wave of neural activity

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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