Abstract
Diarrheal diseases (DD) are leading causes of disease burden, death, and disability, especially in children in low-income settings. DD can also impact a child's potential livelihood through stunted physical growth, cognitive impairment, and other sequelae. As part of the Global Burden of Disease Study, we estimated DD burden, and the burden attributable to specific risk factors and particular etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2013. For both sexes and all ages, we calculated disability-adjusted life years (DALYs), which are the sum of years of life lost and years lived with disability. We estimate that over 125,000 deaths (3.6% of total deaths) were due to DD in the EMR in 2013, with a greater burden of DD in low-and middle-income countries. Diarrhea deaths per 100,000 children under 5 years of age ranged from one (95% uncertainty interval [UI] = 0-1) in Bahrain and Oman to 471 (95% UI = 245-763) in Somalia. The pattern for diarrhea DALYs among those under 5 years of age closely followed that for diarrheal deaths. DALYs per 100,000 ranged from 739 (95% UI = 520-989) in Syria to 40,869 (95% UI = 21,540-65,823) in Somalia. Our results highlighted a highly inequitable burden of DD in EMR, mainly driven by the lack of access to proper resources such as water and sanitation. Our findings will guide preventive and treatment interventions which are based on evidence and which follow the ultimate goal of reducing the DD burden.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1319-1329 |
| Number of pages | 11 |
| Journal | American Journal of Tropical Medicine and Hygiene |
| Volume | 95 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2016 |
ASJC Scopus subject areas
- Parasitology
- Virology
- Infectious Diseases
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Burden of diarrhea in the eastern mediterranean region, 1990-2013 : Findings from the global burden of disease study 2013. / Khalil, Ibrahim; Colombara, Danny V.; Forouzanfar, Mohammad Hossein; Troeger, Christopher; Daoud, Farah; Moradi-Lakeh, Maziar; El Bcheraoui, Charbel; Rao, Puja C.; Afshin, Ashkan; Charara, Raghid; Abate, Kalkidan Hassen; Abd El Razek, Mohammed Magdy; Abd-Allah, Foad; Abu-Elyazeed, Remon; Kiadaliri, Aliasghar Ahmad; Akanda, Ali Shafqat; Akseer, Nadia; Alam, Khurshid; Alasfoor, Deena; Ali, Raghib; AlMazroa, Mohammad A.; Alomari, Mahmoud A.; Salem Al-Raddadi, Rajaa Mohammad; Alsharif, Ubai; Alsowaidi, Shirina; Altirkawi, Khalid A.; Alvis-Guzman, Nelson; Ammar, Walid; Antonio, Carl Abelardo T.; Asayesh, Hamid; Asghar, Rana Jawad; Atique, Suleman; Awasthi, Ashish; Bacha, Umar; Badawi, Alaa; Barac, Aleksandra; Bedi, Neeraj; Bekele, Tolesa; Bensenor, Isabela M.; Betsu, Balem Demtsu; Bhutta, Zulfiqar; Abdulhak, Aref A.Bin; Butt, Zahid A.; Danawi, Hadi; Dubey, Manisha; Endries, Aman Yesuf; Faghmous, Imad M.D.A.; Farid, Talha; Farvid, Maryam S.; Farzadfar, Farshad; Fereshtehnejad, Seyed Mohammad; Fischer, Florian; Anderson Fitchett, Joseph Robert; Gibney, Katherine B.; Mohamed Ginawi, Ibrahim Abdelmageem; Gishu, Melkamu Dedefo; Gugnani, Harish Chander; Gupta, Rahul; Hailu, Gessessew Bugssa; Hamadeh, Randah Ribhi; Hamidi, Samer; Harb, Hilda L.; Hedayati, Mohammad T.; Hsairi, Mohamed; Husseini, Abdullatif; Jahanmehr, Nader; Javanbakht, Mehdi; Jibat, Tariku; Jonas, Jost B.; Kasaeian, Amir; Khader, Yousef Saleh; Khan, Abdur Rahman; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khoja, Tawfik Ahmed Muthafer; Kinfu, Yohannes; Kissoon, Niranjan; Koyanagi, Ai; Lal, Aparna; Abdul Latif, Asma Abdul; Lunevicius, Raimundas; Abd El Razek, Hassan Magdy; Majeed, Azeem; Malekzadeh, Reza; Mehari, Alem; Mekonnen, Alemayehu B.; Melaku, Yohannes Adama; Memish, Ziad A.; Mendoza, Walter; Misganaw, Awoke; Ibrahim Mohamed, Layla Abdalla; Nachega, Jean B.; Nguyen, Quyen Le; Nisar, Muhammad Imran; Peprah, Emmanuel Kwame; Platts-Mills, James A.; Pourmalek, Farshad; Qorbani, Mostafa; Rafay, Anwar; Rahimi-Movaghar, Vafa; Ur Rahman, Sajjad; Rai, Rajesh Kumar; Rana, Saleem M.; Ranabhat, Chhabi L.; Rao, Sowmya R.; Refaat, Amany H.; Riddle, Mark; Roshandel, Gholamreza; Ruhago, George Mugambage; Saleh, Muhammad Muhammad; Sanabria, Juan R.; Sawhney, Monika; Sepanlou, Sadaf G.; Setegn, Tesfaye; Sliwa, Karen; Sreeramareddy, Chandrashekhar T.; Sykes, Bryan L.; Tavakkoli, Mohammad; Tedla, Bemnet Amare; Terkawi, Abdullah S.; Ukwaja, Kingsley; Uthman, Olalekan A.; Westerman, Ronny; Wubshet, Mamo; Yenesew, Muluken A.; Yonemoto, Naohiro; Younis, Mustafa Z.; Zaidi, Zoubida; El Sayed Zaki, Maysaa; Al Rabeeah, Abdullah A.; Wang, Haidong; Naghavi, Mohsen; Vos, Theo; Lopez, Alan D.; Murray, Christopher J.L.; Mokdad, Ali H.
In: American Journal of Tropical Medicine and Hygiene, Vol. 95, No. 6, 12.2016, p. 1319-1329.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Burden of diarrhea in the eastern mediterranean region, 1990-2013
T2 - Findings from the global burden of disease study 2013
AU - Khalil, Ibrahim
AU - Colombara, Danny V.
AU - Forouzanfar, Mohammad Hossein
AU - Troeger, Christopher
AU - Daoud, Farah
AU - Moradi-Lakeh, Maziar
AU - El Bcheraoui, Charbel
AU - Rao, Puja C.
AU - Afshin, Ashkan
AU - Charara, Raghid
AU - Abate, Kalkidan Hassen
AU - Abd El Razek, Mohammed Magdy
AU - Abd-Allah, Foad
AU - Abu-Elyazeed, Remon
AU - Kiadaliri, Aliasghar Ahmad
AU - Akanda, Ali Shafqat
AU - Akseer, Nadia
AU - Alam, Khurshid
AU - Alasfoor, Deena
AU - Ali, Raghib
AU - AlMazroa, Mohammad A.
AU - Alomari, Mahmoud A.
AU - Salem Al-Raddadi, Rajaa Mohammad
AU - Alsharif, Ubai
AU - Alsowaidi, Shirina
AU - Altirkawi, Khalid A.
AU - Alvis-Guzman, Nelson
AU - Ammar, Walid
AU - Antonio, Carl Abelardo T.
AU - Asayesh, Hamid
AU - Asghar, Rana Jawad
AU - Atique, Suleman
AU - Awasthi, Ashish
AU - Bacha, Umar
AU - Badawi, Alaa
AU - Barac, Aleksandra
AU - Bedi, Neeraj
AU - Bekele, Tolesa
AU - Bensenor, Isabela M.
AU - Betsu, Balem Demtsu
AU - Bhutta, Zulfiqar
AU - Abdulhak, Aref A.Bin
AU - Butt, Zahid A.
AU - Danawi, Hadi
AU - Dubey, Manisha
AU - Endries, Aman Yesuf
AU - Faghmous, Imad M.D.A.
AU - Farid, Talha
AU - Farvid, Maryam S.
AU - Farzadfar, Farshad
AU - Fereshtehnejad, Seyed Mohammad
AU - Fischer, Florian
AU - Anderson Fitchett, Joseph Robert
AU - Gibney, Katherine B.
AU - Mohamed Ginawi, Ibrahim Abdelmageem
AU - Gishu, Melkamu Dedefo
AU - Gugnani, Harish Chander
AU - Gupta, Rahul
AU - Hailu, Gessessew Bugssa
AU - Hamadeh, Randah Ribhi
AU - Hamidi, Samer
AU - Harb, Hilda L.
AU - Hedayati, Mohammad T.
AU - Hsairi, Mohamed
AU - Husseini, Abdullatif
AU - Jahanmehr, Nader
AU - Javanbakht, Mehdi
AU - Jibat, Tariku
AU - Jonas, Jost B.
AU - Kasaeian, Amir
AU - Khader, Yousef Saleh
AU - Khan, Abdur Rahman
AU - Khan, Ejaz Ahmad
AU - Khan, Gulfaraz
AU - Khoja, Tawfik Ahmed Muthafer
AU - Kinfu, Yohannes
AU - Kissoon, Niranjan
AU - Koyanagi, Ai
AU - Lal, Aparna
AU - Abdul Latif, Asma Abdul
AU - Lunevicius, Raimundas
AU - Abd El Razek, Hassan Magdy
AU - Majeed, Azeem
AU - Malekzadeh, Reza
AU - Mehari, Alem
AU - Mekonnen, Alemayehu B.
AU - Melaku, Yohannes Adama
AU - Memish, Ziad A.
AU - Mendoza, Walter
AU - Misganaw, Awoke
AU - Ibrahim Mohamed, Layla Abdalla
AU - Nachega, Jean B.
AU - Nguyen, Quyen Le
AU - Nisar, Muhammad Imran
AU - Peprah, Emmanuel Kwame
AU - Platts-Mills, James A.
AU - Pourmalek, Farshad
AU - Qorbani, Mostafa
AU - Rafay, Anwar
AU - Rahimi-Movaghar, Vafa
AU - Ur Rahman, Sajjad
AU - Rai, Rajesh Kumar
AU - Rana, Saleem M.
AU - Ranabhat, Chhabi L.
AU - Rao, Sowmya R.
AU - Refaat, Amany H.
AU - Riddle, Mark
AU - Roshandel, Gholamreza
AU - Ruhago, George Mugambage
AU - Saleh, Muhammad Muhammad
AU - Sanabria, Juan R.
AU - Sawhney, Monika
AU - Sepanlou, Sadaf G.
AU - Setegn, Tesfaye
AU - Sliwa, Karen
AU - Sreeramareddy, Chandrashekhar T.
AU - Sykes, Bryan L.
AU - Tavakkoli, Mohammad
AU - Tedla, Bemnet Amare
AU - Terkawi, Abdullah S.
AU - Ukwaja, Kingsley
AU - Uthman, Olalekan A.
AU - Westerman, Ronny
AU - Wubshet, Mamo
AU - Yenesew, Muluken A.
AU - Yonemoto, Naohiro
AU - Younis, Mustafa Z.
AU - Zaidi, Zoubida
AU - El Sayed Zaki, Maysaa
AU - Al Rabeeah, Abdullah A.
AU - Wang, Haidong
AU - Naghavi, Mohsen
AU - Vos, Theo
AU - Lopez, Alan D.
AU - Murray, Christopher J.L.
AU - Mokdad, Ali H.
N1 - Publisher Copyright: Copyright © 2016 by The American Society of Tropical Medicine and Hygiene. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/12
Y1 - 2016/12
N2 - Diarrheal diseases (DD) are leading causes of disease burden, death, and disability, especially in children in low-income settings. DD can also impact a child's potential livelihood through stunted physical growth, cognitive impairment, and other sequelae. As part of the Global Burden of Disease Study, we estimated DD burden, and the burden attributable to specific risk factors and particular etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2013. For both sexes and all ages, we calculated disability-adjusted life years (DALYs), which are the sum of years of life lost and years lived with disability. We estimate that over 125,000 deaths (3.6% of total deaths) were due to DD in the EMR in 2013, with a greater burden of DD in low-and middle-income countries. Diarrhea deaths per 100,000 children under 5 years of age ranged from one (95% uncertainty interval [UI] = 0-1) in Bahrain and Oman to 471 (95% UI = 245-763) in Somalia. The pattern for diarrhea DALYs among those under 5 years of age closely followed that for diarrheal deaths. DALYs per 100,000 ranged from 739 (95% UI = 520-989) in Syria to 40,869 (95% UI = 21,540-65,823) in Somalia. Our results highlighted a highly inequitable burden of DD in EMR, mainly driven by the lack of access to proper resources such as water and sanitation. Our findings will guide preventive and treatment interventions which are based on evidence and which follow the ultimate goal of reducing the DD burden.
AB - Diarrheal diseases (DD) are leading causes of disease burden, death, and disability, especially in children in low-income settings. DD can also impact a child's potential livelihood through stunted physical growth, cognitive impairment, and other sequelae. As part of the Global Burden of Disease Study, we estimated DD burden, and the burden attributable to specific risk factors and particular etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2013. For both sexes and all ages, we calculated disability-adjusted life years (DALYs), which are the sum of years of life lost and years lived with disability. We estimate that over 125,000 deaths (3.6% of total deaths) were due to DD in the EMR in 2013, with a greater burden of DD in low-and middle-income countries. Diarrhea deaths per 100,000 children under 5 years of age ranged from one (95% uncertainty interval [UI] = 0-1) in Bahrain and Oman to 471 (95% UI = 245-763) in Somalia. The pattern for diarrhea DALYs among those under 5 years of age closely followed that for diarrheal deaths. DALYs per 100,000 ranged from 739 (95% UI = 520-989) in Syria to 40,869 (95% UI = 21,540-65,823) in Somalia. Our results highlighted a highly inequitable burden of DD in EMR, mainly driven by the lack of access to proper resources such as water and sanitation. Our findings will guide preventive and treatment interventions which are based on evidence and which follow the ultimate goal of reducing the DD burden.
UR - http://www.scopus.com/inward/record.url?scp=85005950002&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85005950002&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.16-0339
DO - 10.4269/ajtmh.16-0339
M3 - Article
C2 - 27928080
AN - SCOPUS:85005950002
VL - 95
SP - 1319
EP - 1329
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
SN - 0002-9637
IS - 6
ER -