C. elegans network biology: a beginning.

Fabio Piano, Kristin C. Gunsalus, David E. Hill, Marc Vidal

Research output: Contribution to journalReview articlepeer-review


The architecture and dynamics of molecular networks can provide an understanding of complex biological processes complementary to that obtained from the in-depth study of single genes and proteins. With a completely sequenced and well-annotated genome, a fully characterized cell lineage, and powerful tools available to dissect development, Caenorhabditis elegans, among metazoans, provides an optimal system to bridge cellular and organismal biology with the global properties of macromolecular networks. This chapter considers omic technologies available for C. elegans to describe molecular networks--encompassing transcriptional and phenotypic profiling as well as physical interaction mapping--and discusses how their individual and integrated applications are paving the way for a network-level understanding of C. elegans biology.

Original languageEnglish (US)
Pages (from-to)1-20
Number of pages20
JournalWormBook : the online review of C. elegans biology
StatePublished - 2006

ASJC Scopus subject areas

  • General Medicine


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