[C-H · anion] Interactions mediate the templation and anion binding properties of topologically non-trivial metal-organic structures in aqueous solutions

Two synthetic approaches - temperature variation and anion templation - allowed for the selective formation of a [2]catenane ([2]C⁴⁺) or a trefoil knot (TK⁶⁺), or for the enhanced formation of a Solomon link (SL⁸⁺), all from a simple set of starting materials (Zn(ii) acetate, diformylpyridine (DFP) and a diamino-2,2′-bipyridine (DAB)) in mixed aqueous solutions. The catenane formed exclusively at 90°C in a 1: 1 mixed solvent of D₂O and MeOD. In the presence of bromide ion as template, TK⁶⁺ formed exclusively at 50°C in the same solvent. In the solid state, TK⁶⁺ hosts two bromide ions in its central cavity by forming six C_sp2-H hydrogen bonds. In D₂O, TK⁶⁺, which was originally prepared as a trifluoroacetate (TFA) salt, was found to exchange two TFA counterions for two monovalent anions of different sizes and shapes, which lodged within the knot's central cavity. In contrast to bromide, the larger triflate anion (CF₃SO₃^-) promoted the formation of SL⁸⁺, which was characterized by ¹H NMR spectroscopy and mass spectrometry. Two dimensional heteronuclear ¹⁹F-¹H-HOSEY NMR experiments detected CH⋯F interactions inside the cavity of SL⁸⁺. Thus, the product distribution of this dynamic link forming system is sensitive to temperature and the size and shape of the anion template, and one of the products, TK⁶⁺, is capable of binding a variety of monovalent anions in D₂O with high affinity (with log β₂ values of 4 to 6 being typical).