C-Reactive Protein Levels are Elevated in Patients with Periodontitis and Their CRP Levels May Go Down After Periodontal Therapy

Article Title and Bibliographic Information: A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. Paraskevas S, Huizinga JD, Loos BG. J Clin Periodontol 2008;35(4):277-90. Level of Evidence: Level 1: Good-quality, patient-oriented evidence. Strength of Recommendation Grade: Grade A: Consistent, good-quality patient-oriented evidence. Purpose/Question: Are CRP levels significantly increased in periodontitis patients and what is the effect of periodontal therapy on their CRP levels?. Source of Funding: Industry - Unrestricted grant from Philips Oral Healthcare EMEA. Type of Study/Design: Systematic review and meta-analysis of observational and experimental studies.