Calcitonin receptors in a cloned human breast cancer cell line (MCF 7)

T. J. Martin, D. M. Findlay, I. MacIntyre, J. A. Eisman, V. P. Michelangeli, J. M. Moseley, N. C. Partridge

Research output: Contribution to journalArticlepeer-review

Abstract

A human breast cancer cell line, MCF 7, is shown to possess a specific calcitonin receptor and calcitonin responsive adenylate cyclase, and calcitonin treatment results in activation of cyclic AMP-dependent protein kinase. Studies with several analogues of calcitonin show that the receptor and adenylate cyclase response preserve the ability to discriminate among the structure-function relationships of the calcitonin molecule. The same cell line has been shown recently to possess a receptor for the steroid hormone, 1,25(OH)2-vitamin D. Coexistence in MCF 7 cells of receptors for two calcium-regulating hormones may be related to the osteoclast-like properties of these cells.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalTopics in Catalysis
Volume96
Issue number1
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Biophysics
  • Molecular Biology

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