Calcitonin receptors in a cloned human breast cancer cell line (MCF 7)

T. J. Martin; D. M. Findlay; I. MacIntyre; J. A. Eisman; V. P. Michelangeli; J. M. Moseley; N. C. Partridge

doi:10.1016/0006-291X(80)91193-6

Calcitonin receptors in a cloned human breast cancer cell line (MCF 7)

T. J. Martin, D. M. Findlay, I. MacIntyre, J. A. Eisman, V. P. Michelangeli, J. M. Moseley, N. C. Partridge

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

A human breast cancer cell line, MCF 7, is shown to possess a specific calcitonin receptor and calcitonin responsive adenylate cyclase, and calcitonin treatment results in activation of cyclic AMP-dependent protein kinase. Studies with several analogues of calcitonin show that the receptor and adenylate cyclase response preserve the ability to discriminate among the structure-function relationships of the calcitonin molecule. The same cell line has been shown recently to possess a receptor for the steroid hormone, 1,25(OH)₂-vitamin D. Coexistence in MCF 7 cells of receptors for two calcium-regulating hormones may be related to the osteoclast-like properties of these cells.

Original language	English (US)
Pages (from-to)	150-156
Number of pages	7
Journal	Topics in Catalysis
Volume	96
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(80)91193-6
State	Published - 1980

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Biophysics
Molecular Biology

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10.1016/0006-291X(80)91193-6

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title = "Calcitonin receptors in a cloned human breast cancer cell line (MCF 7)",

abstract = "A human breast cancer cell line, MCF 7, is shown to possess a specific calcitonin receptor and calcitonin responsive adenylate cyclase, and calcitonin treatment results in activation of cyclic AMP-dependent protein kinase. Studies with several analogues of calcitonin show that the receptor and adenylate cyclase response preserve the ability to discriminate among the structure-function relationships of the calcitonin molecule. The same cell line has been shown recently to possess a receptor for the steroid hormone, 1,25(OH)2-vitamin D. Coexistence in MCF 7 cells of receptors for two calcium-regulating hormones may be related to the osteoclast-like properties of these cells.",

author = "Martin, {T. J.} and Findlay, {D. M.} and I. MacIntyre and Eisman, {J. A.} and Michelangeli, {V. P.} and Moseley, {J. M.} and Partridge, {N. C.}",

note = "Funding Information: ACKNOWLEDGEMENTS: This work was supported Cancer Council of Victoria, the National Council of Australia, and the Department",

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doi = "10.1016/0006-291X(80)91193-6",

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AU - Martin, T. J.

AU - Findlay, D. M.

AU - MacIntyre, I.

AU - Eisman, J. A.

AU - Michelangeli, V. P.

AU - Moseley, J. M.

AU - Partridge, N. C.

N1 - Funding Information: ACKNOWLEDGEMENTS: This work was supported Cancer Council of Victoria, the National Council of Australia, and the Department

PY - 1980

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N2 - A human breast cancer cell line, MCF 7, is shown to possess a specific calcitonin receptor and calcitonin responsive adenylate cyclase, and calcitonin treatment results in activation of cyclic AMP-dependent protein kinase. Studies with several analogues of calcitonin show that the receptor and adenylate cyclase response preserve the ability to discriminate among the structure-function relationships of the calcitonin molecule. The same cell line has been shown recently to possess a receptor for the steroid hormone, 1,25(OH)2-vitamin D. Coexistence in MCF 7 cells of receptors for two calcium-regulating hormones may be related to the osteoclast-like properties of these cells.

AB - A human breast cancer cell line, MCF 7, is shown to possess a specific calcitonin receptor and calcitonin responsive adenylate cyclase, and calcitonin treatment results in activation of cyclic AMP-dependent protein kinase. Studies with several analogues of calcitonin show that the receptor and adenylate cyclase response preserve the ability to discriminate among the structure-function relationships of the calcitonin molecule. The same cell line has been shown recently to possess a receptor for the steroid hormone, 1,25(OH)2-vitamin D. Coexistence in MCF 7 cells of receptors for two calcium-regulating hormones may be related to the osteoclast-like properties of these cells.

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Calcitonin receptors in a cloned human breast cancer cell line (MCF 7)

Abstract

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