Can Macula and Optic Nerve Head Parameters Detect Glaucoma Progression in Eyes with Advanced Circumpapillary Retinal Nerve Fiber Layer Damage?

Fabio Lavinsky, Mengfei Wu, Joel S. Schuman, Katie A. Lucy, Mengling Liu, Youngseok Song, Julia Fallon, Maria de Los Angeles Ramos Cadena, Hiroshi Ishikawa, Gadi Wollstein

    Research output: Contribution to journalArticle

    Abstract

    Purpose: To evaluate the ability of OCT optic nerve head (ONH) and macular parameters to detect disease progression in eyes with advanced structural glaucomatous damage of the circumpapillary retinal nerve fiber layer (cRNFL). Design: Longitudinal study. Participants: Forty-four eyes from 37 patients with advanced average cRNFL damage (≤60 μm) followed up for an average of 4.0 years. Methods: All patients were examined with spectral-domain OCT and visual field (VF) assessment during at least 4 visits. Main Outcome Measurements: Visual field mean deviation (MD) and VF index. OCT cRNFL (average, superior, and inferior quadrants), ganglion cell–inner plexiform layer (GCIPL) (average, superior, and inferior), rim area, cup volume, average cup-to-disc (C:D) ratio, and vertical C:D ratio. Results: At baseline, patients had a median VF MD of –10.18 dB and mean cRNFL of 54.55±3.42 μm. The rate of change for MD and VF index were significant. No significant rate of change was noted for cRNFL, whereas significant (P < 0.001) rates were detected for GCIPL (–0.57±0.05 μm/year) and ONH parameters such as rim area (–0.010±0.001 mm2/year). Conclusions: Macula GCIPL and ONH parameters may be useful in tracking progression in patients with advanced glaucoma.

    Original languageEnglish (US)
    Pages (from-to)1907-1912
    Number of pages6
    JournalOphthalmology
    Volume125
    Issue number12
    DOIs
    StatePublished - Dec 2018

    ASJC Scopus subject areas

    • Ophthalmology

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  • Cite this

    Lavinsky, F., Wu, M., Schuman, J. S., Lucy, K. A., Liu, M., Song, Y., Fallon, J., de Los Angeles Ramos Cadena, M., Ishikawa, H., & Wollstein, G. (2018). Can Macula and Optic Nerve Head Parameters Detect Glaucoma Progression in Eyes with Advanced Circumpapillary Retinal Nerve Fiber Layer Damage? Ophthalmology, 125(12), 1907-1912. https://doi.org/10.1016/j.ophtha.2018.05.020