Candidate genes of the 5-lipoxygenase pathway in acute coronary syndrome: A pilot study

Shu Fen Wung, Bradley E. Aouizerat

Research output: Contribution to journalArticle

Abstract

Purpose. The purpose of this pilot study was to examine arachidonate 5-lipoxygenase (ALOX5) and ALOX5-activating protein (ALOX5AP) gene variations in patients with and without acute coronary syndrome (ACS). Methodology. Four and six single nucleotide polymorphisms spanning the ALOX5 and ALOX5AP genes, respectively, were genotyped in 19 non-Hispanic Caucasian patients with ACS and 27 controls. Results. Presence of the common allele of rs9508835 (ALOX5AP) and the minor allele of rs2029253 (ALOX5) were associated with ACS. After adjustment for age, being a carrier of the rs9508835 common allele was associated with an increased risk of ACS (odds ratio = 2.86). Relevance for nursing practice. Through the inhibition of the ALOX5AP gene by downregulation of the leukotriene pathway, the risk of ACS may be decreased in individuals that carry susceptibility allele(s). Knowledge of the genetic basis of treatments that downregulate the leukotriene pathway may prove essential to the care of individuals with ACS.

Original languageEnglish (US)
Pages (from-to)280-292
Number of pages13
JournalBiological Research for Nursing
Volume9
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • 5-lipoxygenase
  • Acute coronary syndrome
  • Genetics
  • Haplotype
  • Myocardial infarction
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Research and Theory

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