@article{23b3fcef20964a9daa353877433c967d,
title = "Carboalumination of Seven-Membered-Ring trans-Alkenes",
abstract = "Seven-membered-ring trans-alkenes undergo rapid hydro- and carboalumination reactions in the absence of a catalyst with complete regio- and diastereoselectivity. Control experiments, including deuterium labeling, adding radical inhibitors, and using a radical clock, suggest that these reactions proceed by a concerted mechanism. The products of the reaction possess a new carbon-aluminum bond that can then undergo subsequent transformations, particularly oxidation, providing functionalized products as single stereoisomers. ",
author = "Greene, {Margaret A.} and Yudong Liu and Sanzone, {Jillian R.} and Woerpel, {K. A.}",
note = "Funding Information: This research was supported by the National Institute of General Medical Sciences of the National Institutes of Health (1R01GM118730). We thank Dr. Chin Lin (NYU) for his assistance with NMR spectroscopy and mass spectrometry. We also thank the Molecular Design Institute of NYU for purchasing a single-crystal diffractometer and Dr. Chunhua Hu (NYU) for his assistance with data collection and structure determination. The Shared Instrumentation Facility in the Department of Chemistry was constructed through the support of the National Center for Research Resources, National Institutes of Health, under Research Facilities Improvement Award number C06 RR-16572-01. NMR spectra acquired with the Bruker Avance 400 and 500 NMR spectrometers were supported by the National Science Foundation (CHE-01162222). The cryogenic probe for the 600 MHz NMR spectrometer was acquired through the support of the National Institutes of Health S10 grant under award number OD016343. Publisher Copyright: {\textcopyright} 2020 American Chemical Society. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = oct,
day = "2",
doi = "10.1021/acs.orglett.0c02711",
language = "English (US)",
volume = "22",
pages = "7518--7521",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "19",
}