Cardiac fibroblasts: Form and function

Shalini Kanekar, Toshiro Hirozanne, Louis Terracio, Thomas K. Borg

Research output: Contribution to journalArticle

Abstract

The formation and structure of the extracellular matrix (ECM) that makes up the cardiac interstitum is well known yet the underlying mechanisms that regulate the interstitum are poorly known. This review focuses on the role of the cardiac fibroblast in the formation and regulation of the ECM components during cardiac development and in response to physiological and pathological stimulation. The role of ECM receptors (integrins), cellular phenotype, and chemical and mechanical signaling by cardiac fibroblasts are discussed.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalCardiovascular Pathology
Volume7
Issue number3
DOIs
StatePublished - May 1998

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cardiology and Cardiovascular Medicine

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