Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Elahu G. Sustarsic; Tao Ma; Matthew D. Lynes; Michael Larsen; Iuliia Karavaeva; Jesper F. Havelund; Carsten H. Nielsen; Mark P. Jedrychowski; Marta Moreno-Torres; Morten Lundh; Kaja Plucinska; Naja Z. Jespersen; Trisha J. Grevengoed; Barbara Kramar; Julia Peics; Jakob B. Hansen; Farnaz Shamsi; Isabel Forss; Ditte Neess; Susanne Keipert; Jianing Wang; Katharina Stohlmann; Ivan Brandslund; Cramer Christensen; Marit E. Jørgensen; Allan Linneberg; Oluf Pedersen; Michael A. Kiebish; Klaus Qvortrup; Xianlin Han; Bente Klarlund Pedersen; Martin Jastroch; Susanne Mandrup; Andreas Kjær; Steven P. Gygi; Torben Hansen; Matthew P. Gillum; Niels Grarup; Brice Emanuelli; Søren Nielsen; Camilla Scheele; Yu Hua Tseng; Nils J. Færgeman; Zachary Gerhart-Hines

doi:10.1016/j.cmet.2018.05.003

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Elahu G. Sustarsic, Tao Ma, Matthew D. Lynes, Michael Larsen, Iuliia Karavaeva, Jesper F. Havelund, Carsten H. Nielsen, Mark P. Jedrychowski, Marta Moreno-Torres, Morten Lundh, Kaja Plucinska, Naja Z. Jespersen, Trisha J. Grevengoed, Barbara Kramar, Julia Peics, Jakob B. Hansen, Farnaz Shamsi, Isabel Forss, Ditte Neess, Susanne KeipertJianing Wang, Katharina Stohlmann, Ivan Brandslund, Cramer Christensen, Marit E. Jørgensen, Allan Linneberg, Oluf Pedersen, Michael A. Kiebish, Klaus Qvortrup, Xianlin Han, Bente Klarlund Pedersen, Martin Jastroch, Susanne Mandrup, Andreas Kjær, Steven P. Gygi, Torben Hansen, Matthew P. Gillum, Niels Grarup, Brice Emanuelli, Søren Nielsen, Camilla Scheele, Yu Hua Tseng, Nils J. Færgeman, Zachary Gerhart-Hines

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and beige fat activation by cold temperature. This single lipid species in thermogenic fat not only shapes adipose mitochondrial bioenergetics but also exerts profound control over whole-body insulin sensitivity and metabolic flexibility.

Original language	English (US)
Pages (from-to)	159-174.e11
Journal	Cell Metabolism
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2018.05.003
State	Published - Jul 3 2018

Keywords

beige adipose
brown adipose
cardiolipin
CHOP-10
CRLS1
insulin resistance
lipid metabolism
mitochondria
phospholipids
thermogenesis

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., ... Gerhart-Hines, Z. (2018). Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Cell Metabolism, 28(1), 159-174.e11. https://doi.org/10.1016/j.cmet.2018.05.003

Sustarsic, EG, Ma, T, Lynes, MD, Larsen, M, Karavaeva, I, Havelund, JF, Nielsen, CH, Jedrychowski, MP, Moreno-Torres, M, Lundh, M, Plucinska, K, Jespersen, NZ, Grevengoed, TJ, Kramar, B, Peics, J, Hansen, JB, Shamsi, F, Forss, I, Neess, D, Keipert, S, Wang, J, Stohlmann, K, Brandslund, I, Christensen, C, Jørgensen, ME, Linneberg, A, Pedersen, O, Kiebish, MA, Qvortrup, K, Han, X, Pedersen, BK, Jastroch, M, Mandrup, S, Kjær, A, Gygi, SP, Hansen, T, Gillum, MP, Grarup, N, Emanuelli, B, Nielsen, S, Scheele, C, Tseng, YH, Færgeman, NJ & Gerhart-Hines, Z 2018, 'Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis', Cell Metabolism, vol. 28, no. 1, pp. 159-174.e11. https://doi.org/10.1016/j.cmet.2018.05.003

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abstract = "Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and beige fat activation by cold temperature. This single lipid species in thermogenic fat not only shapes adipose mitochondrial bioenergetics but also exerts profound control over whole-body insulin sensitivity and metabolic flexibility.",

keywords = "beige adipose, brown adipose, cardiolipin, CHOP-10, CRLS1, insulin resistance, lipid metabolism, mitochondria, phospholipids, thermogenesis",

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AU - Ma, Tao

AU - Lynes, Matthew D.

AU - Larsen, Michael

AU - Karavaeva, Iuliia

AU - Havelund, Jesper F.

AU - Nielsen, Carsten H.

AU - Jedrychowski, Mark P.

AU - Moreno-Torres, Marta

AU - Lundh, Morten

AU - Plucinska, Kaja

AU - Jespersen, Naja Z.

AU - Grevengoed, Trisha J.

AU - Kramar, Barbara

AU - Peics, Julia

AU - Hansen, Jakob B.

AU - Shamsi, Farnaz

AU - Forss, Isabel

AU - Neess, Ditte

AU - Keipert, Susanne

AU - Wang, Jianing

AU - Stohlmann, Katharina

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Jørgensen, Marit E.

AU - Linneberg, Allan

AU - Pedersen, Oluf

AU - Kiebish, Michael A.

AU - Qvortrup, Klaus

AU - Han, Xianlin

AU - Pedersen, Bente Klarlund

AU - Jastroch, Martin

AU - Mandrup, Susanne

AU - Kjær, Andreas

AU - Gygi, Steven P.

AU - Hansen, Torben

AU - Gillum, Matthew P.

AU - Grarup, Niels

AU - Emanuelli, Brice

AU - Nielsen, Søren

AU - Scheele, Camilla

AU - Tseng, Yu Hua

AU - Færgeman, Nils J.

AU - Gerhart-Hines, Zachary

PY - 2018/7/3

Y1 - 2018/7/3

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KW - brown adipose

KW - cardiolipin

KW - CHOP-10

KW - CRLS1

KW - insulin resistance

KW - lipid metabolism

KW - mitochondria

KW - phospholipids

KW - thermogenesis

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Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Abstract

Keywords

ASJC Scopus subject areas

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