Cargo Transport: Two Motors Are Sometimes Better Than One

Steven P. Gross, Michael Vershinin, George T T. Shubeita

Research output: Contribution to journalReview articlepeer-review

Abstract

Molecular motor proteins are crucial for the proper distribution of organelles and vesicles in cells. Much of our current understanding of how motors function stems from studies of single motors moving cargos in vitro. More recently, however, there has been mounting evidence that the cooperation of multiple motors in moving cargos and the regulation of motor-filament affinity could be key mechanisms that cells utilize to regulate cargo transport. Here, we review these recent advances and present a picture of how the different mechanisms of regulating the number of motors moving a cargo could facilitate cellular functions.

Original languageEnglish (US)
Pages (from-to)R478-R486
JournalCurrent Biology
Volume17
Issue number12
DOIs
StatePublished - Jun 19 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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