Ca2+-activated chloride channel ANO1: A new regulator of osteoclast function

Research output: Contribution to journalComment/debatepeer-review


A paper by Sun et al. identified the Ca2+-activated Cl channel anoctamin 1 or ANO1 (TMEM16A) as an important regulator of osteoclast function by interacting with RANKL activating signaling pathways involved in bone resorption. Although Cl transporters (e.g. ClC7, CLIC5) have been known to be involved in the active process of bone resorption, ANO1 appears to control osteoclast differentiation and function to levels beyond those of other Cltransporters. Regulating ANO1 function might be a useful target for therapeutics in osteoporosis.

Original languageEnglish (US)
Article number102633
JournalCell Calcium
StatePublished - Sep 2022

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Ca2+-activated chloride channel ANO1: A new regulator of osteoclast function'. Together they form a unique fingerprint.

Cite this