Catabolism of calcitonin gene-related peptide and substance P by neutral endopeptidase

M. Katayama, J. A. Nadel, N. W. Bunnett, G. U. Di Maria, M. Haxhiu, D. B. Borson

Research output: Contribution to journalArticlepeer-review


Calcitonin gene-related peptide (CGRP) and substance P (SP) are released from sensory nerves upon exposure to irritating stimuli. Neutral endopeptidase (NEP), a membrane-bound peptidase, cleaves many peptides including SP, thereby limiting their biological actions. Recombinant NEP cleaved CGRP1 approximately 88-fold less rapidly than it cleaved SP. The slow cleavage by NEP of CGRP compared to SP suggests that this enzyme is likely to have weaker physiologic effects on CGRP than have been demonstrated for SP.

Original languageEnglish (US)
Pages (from-to)563-567
Number of pages5
Issue number3
StatePublished - 1991


  • CD10
  • E.C.
  • Enkephalinase
  • Enzyme kinetics
  • HPLC
  • Neutral metalloendopeptidase
  • Peptidase inhibitors
  • Peptidases

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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