Abstract
In this paper we show that in phosphodiester transesterification catalyzed by copper(II)-terpyridine complexes both the metal-bound hydroxyl group and the peripheral pendent tertiary amino groups can provide general base catalysis. At neutral pH the pendent amino groups dominate the process because the metal-bound hydroxyl group is protonated. However, the metal-bound hydroxyl group is more effective at high pH, probably due to its higher basicity and/or closer location to the bound substrate.
Original language | English (US) |
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Pages (from-to) | 1107-1110 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 38 |
Issue number | 7 |
DOIs | |
State | Published - Feb 17 1997 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry