Catalysis of phosphodiester transesterification by dinuclear Cu(II) complexes: The role of the second Cu(II) ion

Shanghao Liu; Andrew D. Hamilton

doi:10.1016/S0960-894X(97)00303-X

Catalysis of phosphodiester transesterification by dinuclear Cu(II) complexes: The role of the second Cu(II) ion

Shanghao Liu, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Two novel dinuclear Cu(II) complexes are prepared and shown to be highly active catalysis for phosphodiester transesterification. Comparative studies on the dinuclear complexes and corresponding mononuclear complexes reveal that one dinuclear complex achieves high activity by double Lewis acid and double general base catalysis while the other exploits single Lewis acid and double general base catalysis.

Original language	English (US)
Pages (from-to)	1779-1784
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(97)00303-X
State	Published - Jul 8 1997

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(97)00303-X

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title = "Catalysis of phosphodiester transesterification by dinuclear Cu(II) complexes: The role of the second Cu(II) ion",

abstract = "Two novel dinuclear Cu(II) complexes are prepared and shown to be highly active catalysis for phosphodiester transesterification. Comparative studies on the dinuclear complexes and corresponding mononuclear complexes reveal that one dinuclear complex achieves high activity by double Lewis acid and double general base catalysis while the other exploits single Lewis acid and double general base catalysis.",

author = "Shanghao Liu and Hamilton, {Andrew D.}",

note = "Funding Information: Acknowledgment. We thank the National Institutes of Health (GM 53579) for financial support.",

year = "1997",

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doi = "10.1016/S0960-894X(97)00303-X",

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T1 - Catalysis of phosphodiester transesterification by dinuclear Cu(II) complexes

T2 - The role of the second Cu(II) ion

AU - Liu, Shanghao

AU - Hamilton, Andrew D.

N1 - Funding Information: Acknowledgment. We thank the National Institutes of Health (GM 53579) for financial support.

PY - 1997/7/8

Y1 - 1997/7/8

N2 - Two novel dinuclear Cu(II) complexes are prepared and shown to be highly active catalysis for phosphodiester transesterification. Comparative studies on the dinuclear complexes and corresponding mononuclear complexes reveal that one dinuclear complex achieves high activity by double Lewis acid and double general base catalysis while the other exploits single Lewis acid and double general base catalysis.

AB - Two novel dinuclear Cu(II) complexes are prepared and shown to be highly active catalysis for phosphodiester transesterification. Comparative studies on the dinuclear complexes and corresponding mononuclear complexes reveal that one dinuclear complex achieves high activity by double Lewis acid and double general base catalysis while the other exploits single Lewis acid and double general base catalysis.

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U2 - 10.1016/S0960-894X(97)00303-X

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ER -

Catalysis of phosphodiester transesterification by dinuclear Cu(II) complexes: The role of the second Cu(II) ion

Abstract

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