Catalysis of phosphodiester transesterification by dinuclear Cu(II) complexes: The role of the second Cu(II) ion

Shanghao Liu, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

Two novel dinuclear Cu(II) complexes are prepared and shown to be highly active catalysis for phosphodiester transesterification. Comparative studies on the dinuclear complexes and corresponding mononuclear complexes reveal that one dinuclear complex achieves high activity by double Lewis acid and double general base catalysis while the other exploits single Lewis acid and double general base catalysis.

Original languageEnglish (US)
Pages (from-to)1779-1784
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number13
DOIs
StatePublished - Jul 8 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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