TY - JOUR
T1 - Cavernous malformation within a schwannoma
T2 - Review of the literature and hypothesis of a common genetic etiology
AU - Feiz-Erfan, I.
AU - Zabramski, J. M.
AU - Herrmann, L. L.
AU - Coons, S. W.
PY - 2006/6
Y1 - 2006/6
N2 - The finding of cavernous malformations within tumors of the central or peripheral nervous system is a rare occurrence. We report a case of a histologically proven cavernous malformation found within an eighth cranial nerve schwannoma in a 76-year-old man. The patient presented with progressive loss of hearing on the left, facial pain and dysesthesia. Symptoms improved significantly after the tumor was subtotally resected through a left retrosigmoid craniotomy. Including the present report, 34 cases of cavernous malformations associated with tumors of nervous system origin, 24 cases (71%) involving tumors of Schwann cell origin, and 9 cases (26%) involving gliomas have been published. The cases were classified into two forms based on the type of association. Conjoined association, in which the cavernous malformation is located within the tissue of the nervous system tumor, and discrete association, in which the cavernous malformation and nervous system tumor are in separate locations. We explore the etiology of this association and hypothesize that a common genetic pathway may be involved in a majority of these cases.
AB - The finding of cavernous malformations within tumors of the central or peripheral nervous system is a rare occurrence. We report a case of a histologically proven cavernous malformation found within an eighth cranial nerve schwannoma in a 76-year-old man. The patient presented with progressive loss of hearing on the left, facial pain and dysesthesia. Symptoms improved significantly after the tumor was subtotally resected through a left retrosigmoid craniotomy. Including the present report, 34 cases of cavernous malformations associated with tumors of nervous system origin, 24 cases (71%) involving tumors of Schwann cell origin, and 9 cases (26%) involving gliomas have been published. The cases were classified into two forms based on the type of association. Conjoined association, in which the cavernous malformation is located within the tissue of the nervous system tumor, and discrete association, in which the cavernous malformation and nervous system tumor are in separate locations. We explore the etiology of this association and hypothesize that a common genetic pathway may be involved in a majority of these cases.
KW - Cavernous malformation
KW - Co-occurrence
KW - Genetic etiology
KW - Glioma
KW - Schwannoma
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U2 - 10.1007/s00701-005-0716-y
DO - 10.1007/s00701-005-0716-y
M3 - Review article
C2 - 16450046
AN - SCOPUS:33745058750
SN - 0001-6268
VL - 148
SP - 647
EP - 652
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
IS - 6
ER -