CCAAT Enhancer Binding Proteins in the Nervous System: Their Role in Development, Differentiation, Long-Term Synaptic Plasticity, and Memory

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The CCAAT enhancer binding protein (C/EBP) family of transcription factors is expressed in several cell types, and is implicated in acute phase responses, stress, and terminal differentiation. In the central nervous system (CNS), C/EBPs are expressed in neurons, where they play a role in developmental neurogenesis, neuronal differentiation, and apoptosis. They are also expressed in glia, where they participate in the regulation of energy metabolism and in responses to inflammation. Finally, as part of the gene cascade regulated by cAMP and cAMP response element binding protein (CREB), C/EBP family members play critical roles during long-term synaptic plasticity and memory formation.

Original languageEnglish (US)
Title of host publicationTranscription Factors in the Nervous System
Subtitle of host publicationDevelopment, Brain Function, and Diseases
PublisherWiley-VCH Verlag GmbH & Co. KGaA
Pages243-258
Number of pages16
ISBN (Print)3527312854, 9783527312856
DOIs
StatePublished - May 22 2006

Keywords

  • Brain function
  • C/EBP expression in glia
  • CCAAT enhancer binding proteins (C/EBPs)
  • Long-term synaptic plasticity
  • Memory
  • Nervous system
  • Role in development
  • Role in differentiation
  • Transcription factors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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