CD4 lymphocytopenia among injecting drug users in new york city

Don C.Des Jarlais; Samuel R. Friedman; Michael Marmor; Donna Mildvan; Stanley Yancovitz; Jo L. Sotheran; John Wenston; Sara Beatrice

CD4 lymphocytopenia among injecting drug users in new york city

Don C.Des Jarlais, Samuel R. Friedman, Michael Marmor, Donna Mildvan, Stanley Yancovitz, Jo L. Sotheran, John Wenston, Sara Beatrice

Global Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Recent cases of “AIDS-like”CD4 lymphocytopenia in the absence of HIV infection have generated considerable scientific and public interest. We studied CD4 cell counts and percentages from 1984 to 1992 among 1, 246 HIV-seronegative injecting drug users in New York City, a population at very high risk for exposure to bloodborne pathogens. Severe CD4 lymphocytopenia was rare, and there was no evidence of an increase over time. Of 229 subjects with longitudinal data, only four met the surveillance definition for “idiopathic CD4 lymphocytopenia”(ICL). CD4 cell counts of <500 cells/µl were, however, associated with subsequent HIV seroconversion (12.7/100 person-years at risk, relative risk (RR) = 4.53, 95% exact binomial confidence interval (CI) 1.7-10.7, p = 0.002).

Original language	English (US)
Pages (from-to)	820-822
Number of pages	3
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	6
Issue number	7
State	Published - Jul 1993

Keywords

CD4 cells
HIV
Injecting drug users
Lymphocytopenia

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

Cite this

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title = "CD4 lymphocytopenia among injecting drug users in new york city",

abstract = "Recent cases of “AIDS-like”CD4 lymphocytopenia in the absence of HIV infection have generated considerable scientific and public interest. We studied CD4 cell counts and percentages from 1984 to 1992 among 1, 246 HIV-seronegative injecting drug users in New York City, a population at very high risk for exposure to bloodborne pathogens. Severe CD4 lymphocytopenia was rare, and there was no evidence of an increase over time. Of 229 subjects with longitudinal data, only four met the surveillance definition for “idiopathic CD4 lymphocytopenia”(ICL). CD4 cell counts of <500 cells/µl were, however, associated with subsequent HIV seroconversion (12.7/100 person-years at risk, relative risk (RR) = 4.53, 95% exact binomial confidence interval (CI) 1.7-10.7, p = 0.002).",

keywords = "CD4 cells, HIV, Injecting drug users, Lymphocytopenia",

author = "Jarlais, {Don C.Des} and Friedman, {Samuel R.} and Michael Marmor and Donna Mildvan and Stanley Yancovitz and Sotheran, {Jo L.} and John Wenston and Sara Beatrice",

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month = jul,

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T1 - CD4 lymphocytopenia among injecting drug users in new york city

AU - Jarlais, Don C.Des

AU - Friedman, Samuel R.

AU - Marmor, Michael

AU - Mildvan, Donna

AU - Yancovitz, Stanley

AU - Sotheran, Jo L.

AU - Wenston, John

AU - Beatrice, Sara

PY - 1993/7

Y1 - 1993/7

N2 - Recent cases of “AIDS-like”CD4 lymphocytopenia in the absence of HIV infection have generated considerable scientific and public interest. We studied CD4 cell counts and percentages from 1984 to 1992 among 1, 246 HIV-seronegative injecting drug users in New York City, a population at very high risk for exposure to bloodborne pathogens. Severe CD4 lymphocytopenia was rare, and there was no evidence of an increase over time. Of 229 subjects with longitudinal data, only four met the surveillance definition for “idiopathic CD4 lymphocytopenia”(ICL). CD4 cell counts of <500 cells/µl were, however, associated with subsequent HIV seroconversion (12.7/100 person-years at risk, relative risk (RR) = 4.53, 95% exact binomial confidence interval (CI) 1.7-10.7, p = 0.002).

AB - Recent cases of “AIDS-like”CD4 lymphocytopenia in the absence of HIV infection have generated considerable scientific and public interest. We studied CD4 cell counts and percentages from 1984 to 1992 among 1, 246 HIV-seronegative injecting drug users in New York City, a population at very high risk for exposure to bloodborne pathogens. Severe CD4 lymphocytopenia was rare, and there was no evidence of an increase over time. Of 229 subjects with longitudinal data, only four met the surveillance definition for “idiopathic CD4 lymphocytopenia”(ICL). CD4 cell counts of <500 cells/µl were, however, associated with subsequent HIV seroconversion (12.7/100 person-years at risk, relative risk (RR) = 4.53, 95% exact binomial confidence interval (CI) 1.7-10.7, p = 0.002).

KW - CD4 cells

KW - HIV

KW - Injecting drug users

KW - Lymphocytopenia

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ER -

CD4 lymphocytopenia among injecting drug users in new york city

Abstract

Keywords

ASJC Scopus subject areas

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