CE: Opioid Use Disorder: Pathophysiology, Assessment, and Effective Interventions

Kate Garland Brown, Bernadette Capili

Research output: Contribution to journalArticlepeer-review


Opioid use disorder (OUD) is a chronic, relapsing disease. Genetic variability, dysregulated stress system response, and history of opioid experimentation or escalating exposure all contribute to the likelihood of developing OUD, which produces complex brain changes that make it difficult to stop opioid use. Understanding the neurobiology of OUD helps nurses anticipate the behaviors of patients with OUD and approach them with empathy. Here, the authors discuss the pathophysiology of OUD, available screening tools, medical treatments, and behavioral interventions that have demonstrated efficacy in reducing substance use.

Original languageEnglish (US)
Pages (from-to)38-46
Number of pages9
JournalThe American journal of nursing
Issue number6
StatePublished - Jun 1 2020

ASJC Scopus subject areas

  • Nursing(all)


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