TY - JOUR
T1 - Cell Cycle Heritability and Localization Phase Transition in Growing Populations
AU - Nozoe, Takashi
AU - Kussell, Edo
N1 - Publisher Copyright:
© 2020 American Physical Society. All rights reserved.
PY - 2020/12/29
Y1 - 2020/12/29
N2 - The cell cycle duration is a variable cellular phenotype that underlies long-term population growth and age structures. By analyzing the stationary solutions of a branching process with heritable cell division times, we demonstrate the existence of a phase transition, which can be continuous or first order, by which a nonzero fraction of the population becomes localized at a minimal division time. Just below the transition, we demonstrate the coexistence of localized and delocalized age-structure phases and the power law decay of correlation functions. Above it, we observe the self-synchronization of cell cycles, collective divisions, and the slow "aging" of population growth rates.
AB - The cell cycle duration is a variable cellular phenotype that underlies long-term population growth and age structures. By analyzing the stationary solutions of a branching process with heritable cell division times, we demonstrate the existence of a phase transition, which can be continuous or first order, by which a nonzero fraction of the population becomes localized at a minimal division time. Just below the transition, we demonstrate the coexistence of localized and delocalized age-structure phases and the power law decay of correlation functions. Above it, we observe the self-synchronization of cell cycles, collective divisions, and the slow "aging" of population growth rates.
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U2 - 10.1103/PhysRevLett.125.268103
DO - 10.1103/PhysRevLett.125.268103
M3 - Article
C2 - 33449732
AN - SCOPUS:85099162169
SN - 0031-9007
VL - 125
JO - Physical Review Letters
JF - Physical Review Letters
IS - 26
M1 - 268103
ER -