Cell Cycle Heritability and Localization Phase Transition in Growing Populations

Takashi Nozoe, Edo Kussell

Research output: Contribution to journalArticlepeer-review

Abstract

The cell cycle duration is a variable cellular phenotype that underlies long-term population growth and age structures. By analyzing the stationary solutions of a branching process with heritable cell division times, we demonstrate the existence of a phase transition, which can be continuous or first order, by which a nonzero fraction of the population becomes localized at a minimal division time. Just below the transition, we demonstrate the coexistence of localized and delocalized age-structure phases and the power law decay of correlation functions. Above it, we observe the self-synchronization of cell cycles, collective divisions, and the slow "aging" of population growth rates.

Original languageEnglish (US)
Article number268103
JournalPhysical Review Letters
Volume125
Issue number26
DOIs
StatePublished - Dec 29 2020

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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