Cell interaction with microtextured surfaces

J. L. Ricci, R. Rose, J. K. Charvet, H. Alexander, C. S. Naiman

Research output: Contribution to conferencePaperpeer-review


The effect of defined surface microgeometry on connective tissue cell colony density, cell attachment area and cell shape was investigated. Rat tendon fibroblast (RTF) cells were grown as stock cultures from hindfoot extensors tendons from 14-day-old Sprague-Dawley rats. Cell colonies were grown on these surfaces using a `dot' culture model similar to explant culture models. Light microscopy and image analysis methods were used to measure rate and direction of growth as well as cell density, cell attachment area, cell orientation and cell elongation. The microgrooved surfaces reduced cell colony growth and cell spreading, increased cell eccentricity and effectively oriented the cells parallel to the surface.

Original languageEnglish (US)
Number of pages1
StatePublished - 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996


OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can

ASJC Scopus subject areas

  • General Materials Science


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