Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6

Javier Morante, Ted Erclik, Claude Desplan

Research output: Contribution to journalArticle

Abstract

In the developing Drosophila optic lobe, eyeless, apterous and distal-less, three genes that encode transcription factors with important functions during development, are expressed in broad subsets of medulla neurons. Medulla cortex cells follow two patterns of cell movements to acquire their final position: first, neurons are arranged in columns below each neuroblast. Then, during pupation, they migrate laterally, intermingling with each other to reach their retinotopic position in the adult optic lobe. eyeless, which encodes a Pax6 transcription factor, is expressed early in progenitors and controls aspects of this cell migration. Its loss in medulla neurons leads to overgrowth and a failure of lateral migration during pupation. These defects in cell migration among medulla cortex cells can be rescued by removing DE-Cadherin. Thus, eyeless links neurogenesis and neuronal migration.

Original languageEnglish (US)
Pages (from-to)687-693
Number of pages7
JournalDevelopment
Volume138
Issue number4
DOIs
StatePublished - Feb 15 2011

Keywords

  • Cell adhesion
  • Cell migration
  • Neuroblast
  • Optic lobe

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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