Cell-permeable scavengers of superoxide prevent long-term potentiation in hippocampal area CA1

Research output: Contribution to journalArticlepeer-review


Long-term potentiation (LTP) in hippocampal area CA1 is generally dependent on N-methyl-D-aspartate (NMDA) receptor activation. Reactive oxygen species (ROS), including superoxide, are produced in response to NMDA receptor activation in a number of brain regions, including the hipppocampus. In this study, two cell-permeable manganese porphyrin compounds that mimic superoxide dismutase (SOD) were used to determine whether production of superoxide is required for the induction of LTP in area CA1 of rat hippocampal slices. Incubation of hippocampal slices with either Mn(III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) or Mn(III) tetrakis (1-methyl- 4-pyridyl) porphyrin (MnTMPyP) prevented the induction of LTP. Incubation of slices with either light-inactivated MnTBAP or light-inactivated MnTMPyP had no effect on induction of LTP. Neither MnTBAP nor MnTMPyP was able to reverse preestablished LTP. These observations suggest that production of superoxide occurs in response to LTP-inducing stimulation and that superoxide is necessary for the induction of LTP.

Original languageEnglish (US)
Pages (from-to)452-457
Number of pages6
JournalJournal of neurophysiology
Issue number1
StatePublished - Jul 1998

ASJC Scopus subject areas

  • General Neuroscience
  • Physiology


Dive into the research topics of 'Cell-permeable scavengers of superoxide prevent long-term potentiation in hippocampal area CA1'. Together they form a unique fingerprint.

Cite this