Cell reprogramming: The many roads to success

Begüm Aydin, Esteban O. Mazzoni

Research output: Contribution to journalReview article

Abstract

Cellular reprogramming experiments from somatic cell types have demonstrated the plasticity of terminally differentiated cell states. Recent efforts in understanding the mechanisms of cellular reprogramming have begun to elucidate the differentiation trajectories along the reprogramming processes. In this review, we focus mainly on direct reprogramming strategies by transcription factors and highlight the variables that contribute to cell fate conversion outcomes. We review key studies that shed light on the cellular and molecular mechanisms by investigating differentiation trajectories and alternative cell states as well as transcription factor regulatory activities during cell fate reprogramming. Finally, we highlight a few concepts that we believe require attention, particularly when measuring the success of cell reprogramming experiments.

Original languageEnglish (US)
Pages (from-to)433-452
Number of pages20
JournalAnnual Review of Cell and Developmental Biology
Volume35
DOIs
StatePublished - 2019

Keywords

  • cellular reprogramming strategies
  • differentiation trajectories
  • mechanisms of direct reprogramming
  • transcription factors
  • transdifferentiation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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