Cell type-specific connectome predicts distributed working memory activity in the mouse brain

Xingyu Ding, Sean Froudist-Walsh, Jorge Jaramillo, Junjie Jiang, Xiao Jing Wang

Research output: Contribution to journalArticlepeer-review


Recent advances in connectomics and neurophysiology make it possible to probe whole-brain mechanisms of cognition and behavior. We developed a large-scale model of the multi-regional mouse brain for a cardinal cognitive function called working memory, the brain’s ability to internally hold and process information without sensory input. The model is built on mesoscopic connectome data for interareal cortical connections and endowed with a macroscopic gradient of measured parvalbumin-expressing interneuron density. We found that working memory coding is distributed yet exhibits modularity; the spatial pattern of mnemonic representation is determined by long-range cell type-specific targeting and density of cell classes. Cell type-specific graph measures predict the activity patterns and a core subnetwork for memory maintenance. The model shows numerous attractor states, which are self-sustained internal states (each engaging a distinct subset of areas). This work provides a framework to interpret large-scale recordings of brain activity during cognition, while highlighting the need for cell type-specific connectomics.

Original languageEnglish (US)
Article numbere85442
StatePublished - 2024

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


Dive into the research topics of 'Cell type-specific connectome predicts distributed working memory activity in the mouse brain'. Together they form a unique fingerprint.

Cite this