Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

Hyeseung Lee; Robert J. Fenster; S. Sebastian Pineda; Whitney S. Gibbs; Shahin Mohammadi; Jose Davila-Velderrain; Francisco J. Garcia; Martine Therrien; Hailey S. Novis; Fan Gao; Hilary Wilkinson; Thomas Vogt; Manolis Kellis; Matthew J. LaVoie; Myriam Heiman

doi:10.1016/j.neuron.2020.06.021

Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

Hyeseung Lee, Robert J. Fenster, S. Sebastian Pineda, Whitney S. Gibbs, Shahin Mohammadi, Jose Davila-Velderrain, Francisco J. Garcia, Martine Therrien, Hailey S. Novis, Fan Gao, Hilary Wilkinson, Thomas Vogt, Manolis Kellis, Matthew J. LaVoie, Myriam Heiman

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Lee, Fenster, et al. conduct striatal cell type-specific transcriptomics in mouse models of HD and human HD. Their findings reveal that mutant huntingtin leads to the release of mitochondrial RNAs and activation of innate immune signaling in neurons in a manner that correlates with striatal cell vulnerability in HD.

Original language	English (US)
Pages (from-to)	891-908.e8
Journal	Neuron
Volume	107
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2020.06.021
State	Published - Sep 9 2020

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2020.06.021

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Lee, H., Fenster, R. J., Pineda, S. S., Gibbs, W. S., Mohammadi, S., Davila-Velderrain, J., Garcia, F. J., Therrien, M., Novis, H. S., Gao, F., Wilkinson, H., Vogt, T., Kellis, M., LaVoie, M. J., & Heiman, M. (2020). Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation. Neuron, 107(5), 891-908.e8. https://doi.org/10.1016/j.neuron.2020.06.021

Lee, H, Fenster, RJ, Pineda, SS, Gibbs, WS, Mohammadi, S, Davila-Velderrain, J, Garcia, FJ, Therrien, M, Novis, HS, Gao, F, Wilkinson, H, Vogt, T, Kellis, M, LaVoie, MJ & Heiman, M 2020, 'Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation', Neuron, vol. 107, no. 5, pp. 891-908.e8. https://doi.org/10.1016/j.neuron.2020.06.021

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title = "Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation",

abstract = "Lee, Fenster, et al. conduct striatal cell type-specific transcriptomics in mouse models of HD and human HD. Their findings reveal that mutant huntingtin leads to the release of mitochondrial RNAs and activation of innate immune signaling in neurons in a manner that correlates with striatal cell vulnerability in HD.",

author = "Hyeseung Lee and Fenster, {Robert J.} and Pineda, {S. Sebastian} and Gibbs, {Whitney S.} and Shahin Mohammadi and Jose Davila-Velderrain and Garcia, {Francisco J.} and Martine Therrien and Novis, {Hailey S.} and Fan Gao and Hilary Wilkinson and Thomas Vogt and Manolis Kellis and LaVoie, {Matthew J.} and Myriam Heiman",

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year = "2020",

month = sep,

day = "9",

doi = "10.1016/j.neuron.2020.06.021",

language = "English (US)",

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AU - Lee, Hyeseung

AU - Fenster, Robert J.

AU - Pineda, S. Sebastian

AU - Gibbs, Whitney S.

AU - Mohammadi, Shahin

AU - Davila-Velderrain, Jose

AU - Garcia, Francisco J.

AU - Therrien, Martine

AU - Novis, Hailey S.

AU - Gao, Fan

AU - Wilkinson, Hilary

AU - Vogt, Thomas

AU - Kellis, Manolis

AU - LaVoie, Matthew J.

AU - Heiman, Myriam

PY - 2020/9/9

Y1 - 2020/9/9

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AB - Lee, Fenster, et al. conduct striatal cell type-specific transcriptomics in mouse models of HD and human HD. Their findings reveal that mutant huntingtin leads to the release of mitochondrial RNAs and activation of innate immune signaling in neurons in a manner that correlates with striatal cell vulnerability in HD.

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Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

Abstract

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