Cell Types, Network Homeostasis, and Pathological Compensation from a Biologically Plausible Ion Channel Expression Model

Timothy O'Leary, Alex H. Williams, Alessio Franci, Eve Marder

Research output: Contribution to journalArticlepeer-review

Abstract

How do neurons develop, control, and maintain their electrical signaling properties in spite of ongoing protein turnover and perturbations to activity? From generic assumptions about the molecular biology underlying channel expression, we derive a simple model and show how it encodes an "activity set point" in single neurons. The model generates diverse self-regulating cell types and relates correlations in conductance expression observed invivo to underlying channel expression rates. Synaptic as well as intrinsic conductances can be regulated to make aself-assembling central pattern generator network;thus, network-level homeostasis can emerge fromcell-autonomous regulation rules. Finally, we demonstrate that the outcome of homeostatic regulation depends on the complement of ion channels expressed in cells: in some cases, loss of specific ion channels can be compensated; in others, the homeostatic mechanism itself causes pathological loss of function.

Original languageEnglish (US)
Pages (from-to)809-821
Number of pages13
JournalNeuron
Volume82
Issue number4
DOIs
StatePublished - May 21 2014

ASJC Scopus subject areas

  • Neuroscience(all)

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