Long-term habituation training in Aplysia californica produces a profound depression in the efficacy of synaptic transmission between mechanoreceptor neurons and gill motor neurons. This depression persists for more than 3 weeks. Thus a critical synoptic site for plasticity underlying long-term habituation is the same as that for short-term habituation. For this simple form of learning, short- and longterm memory share a common locus and aspects of a common mechanism: synaptic depression.
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