Cellular clockwork

Michael N. Nitabach, Justin Blau

Research output: Contribution to journalShort surveypeer-review


A new study identifies a cell-autonomous two-hour clock in diverse types of mammalian cells in culture. The two-hour oscillations depend on negative feedback of a gene product, Hes1, on transcription of its own gene - a regulatory mechanism that is identical to the circadian clock. Although a similar two-hour clock is required for vertebrate somitogenesis, the physiological role of the two-hour clock in cells remains unclear.

Original languageEnglish (US)
Pages (from-to)559-560
Number of pages2
JournalNature Genetics
Issue number4
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Genetics


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