Abstract
A new study identifies a cell-autonomous two-hour clock in diverse types of mammalian cells in culture. The two-hour oscillations depend on negative feedback of a gene product, Hes1, on transcription of its own gene - a regulatory mechanism that is identical to the circadian clock. Although a similar two-hour clock is required for vertebrate somitogenesis, the physiological role of the two-hour clock in cells remains unclear.
Original language | English (US) |
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Pages (from-to) | 559-560 |
Number of pages | 2 |
Journal | Nature Genetics |
Volume | 32 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1 2002 |
ASJC Scopus subject areas
- Genetics