Abstract
Mice infected with influenza virus develop cytotoxic T lymphocytes (CTL) specific for viral antigens prior to the appearance of virus-specific antibody-forming cells (AFCs). Effector T cells were detected at a time coincident with a precipitous decline in pulmonary virus titer. CTLs of draining lymph nodes and spleen were found to be cross-reactive among H-2 compatible cells infected with influenza type A virus subtypes. AFCs were observed to be primarily hemagglutinin specific. Virus-specific IgA-secreting AFCs were detected in mediastinal lymph nodes of infected mice.
Original language | English (US) |
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Pages (from-to) | 502-509 |
Number of pages | 8 |
Journal | Cellular Immunology |
Volume | 56 |
Issue number | 2 |
DOIs | |
State | Published - Dec 1980 |
ASJC Scopus subject areas
- Immunology