Cellular immune responses of mice to influenza virus infection

Carol S. Reiss, Jerome L. Schulman

Research output: Contribution to journalArticlepeer-review


Mice infected with influenza virus develop cytotoxic T lymphocytes (CTL) specific for viral antigens prior to the appearance of virus-specific antibody-forming cells (AFCs). Effector T cells were detected at a time coincident with a precipitous decline in pulmonary virus titer. CTLs of draining lymph nodes and spleen were found to be cross-reactive among H-2 compatible cells infected with influenza type A virus subtypes. AFCs were observed to be primarily hemagglutinin specific. Virus-specific IgA-secreting AFCs were detected in mediastinal lymph nodes of infected mice.

Original languageEnglish (US)
Pages (from-to)502-509
Number of pages8
JournalCellular Immunology
Issue number2
StatePublished - Dec 1980

ASJC Scopus subject areas

  • Immunology


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