Abstract
Mice infected with influenza virus develop cytotoxic T lymphocytes (CTL) specific for viral antigens prior to the appearance of virus-specific antibody-forming cells (AFCs). Effector T cells were detected at a time coincident with a precipitous decline in pulmonary virus titer. CTLs of draining lymph nodes and spleen were found to be cross-reactive among H-2 compatible cells infected with influenza type A virus subtypes. AFCs were observed to be primarily hemagglutinin specific. Virus-specific IgA-secreting AFCs were detected in mediastinal lymph nodes of infected mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 502-509 |
| Number of pages | 8 |
| Journal | Cellular Immunology |
| Volume | 56 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 1980 |
ASJC Scopus subject areas
- Immunology
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Cite this
Reiss, C. S., & Schulman, J. L. (1980). Cellular immune responses of mice to influenza virus infection. Cellular Immunology, 56(2), 502-509. https://doi.org/10.1016/0008-8749(80)90124-0