Cellular immune responses of mice to influenza virus infection

Carol S. Reiss; Jerome L. Schulman

doi:10.1016/0008-8749(80)90124-0

Cellular immune responses of mice to influenza virus infection

Carol S. Reiss, Jerome L. Schulman

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Mice infected with influenza virus develop cytotoxic T lymphocytes (CTL) specific for viral antigens prior to the appearance of virus-specific antibody-forming cells (AFCs). Effector T cells were detected at a time coincident with a precipitous decline in pulmonary virus titer. CTLs of draining lymph nodes and spleen were found to be cross-reactive among H-2 compatible cells infected with influenza type A virus subtypes. AFCs were observed to be primarily hemagglutinin specific. Virus-specific IgA-secreting AFCs were detected in mediastinal lymph nodes of infected mice.

Original language	English (US)
Pages (from-to)	502-509
Number of pages	8
Journal	Cellular Immunology
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(80)90124-0
State	Published - Dec 1980

ASJC Scopus subject areas

Immunology

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abstract = "Mice infected with influenza virus develop cytotoxic T lymphocytes (CTL) specific for viral antigens prior to the appearance of virus-specific antibody-forming cells (AFCs). Effector T cells were detected at a time coincident with a precipitous decline in pulmonary virus titer. CTLs of draining lymph nodes and spleen were found to be cross-reactive among H-2 compatible cells infected with influenza type A virus subtypes. AFCs were observed to be primarily hemagglutinin specific. Virus-specific IgA-secreting AFCs were detected in mediastinal lymph nodes of infected mice.",

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