Cellular immune responses of mice to influenza virus vaccines

C. S. Reiss, J. L. Schulman

Research output: Contribution to journalArticle

Abstract

Parenteral sensitization of mice with equivalent amounts of untreated, gradient-purified or UV-inactivated influenza A/PR/8/34 virus (PR8 virus) results in the stimulation of maximal serum antibody titers, greatest numbers of antibody-forming cells (AFC), and strong virus-specific cytotoxic T lymphocyte (CTL) activity. In contrast, inoculation of formalin-inactivated virus, which induced antibody titers of equivalent magnitude, did not elicit a measurable primary CTL response nor prime for a secondary response. However, in mice previously exposed to untreated virus, challenge with formalin-inactivated virus evoked a secondary CTL response. Immunization of unprimed mice with aggregated viral glycoproteins or detergent-disrupted virus vaccine was much less immunogenic for antibody and AFC response and did not evoke measurable primary, secondary, or memory cytotoxic effector cells in vivo.

Original languageEnglish (US)
Pages (from-to)2182-2188
Number of pages7
JournalJournal of Immunology
Volume125
Issue number5
StatePublished - 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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