TY - JOUR
T1 - Cellular immune responses of mice to influenza virus vaccines
AU - Reiss, C. S.
AU - Schulman, J. L.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1980
Y1 - 1980
N2 - Parenteral sensitization of mice with equivalent amounts of untreated, gradient-purified or UV-inactivated influenza A/PR/8/34 virus (PR8 virus) results in the stimulation of maximal serum antibody titers, greatest numbers of antibody-forming cells (AFC), and strong virus-specific cytotoxic T lymphocyte (CTL) activity. In contrast, inoculation of formalin-inactivated virus, which induced antibody titers of equivalent magnitude, did not elicit a measurable primary CTL response nor prime for a secondary response. However, in mice previously exposed to untreated virus, challenge with formalin-inactivated virus evoked a secondary CTL response. Immunization of unprimed mice with aggregated viral glycoproteins or detergent-disrupted virus vaccine was much less immunogenic for antibody and AFC response and did not evoke measurable primary, secondary, or memory cytotoxic effector cells in vivo.
AB - Parenteral sensitization of mice with equivalent amounts of untreated, gradient-purified or UV-inactivated influenza A/PR/8/34 virus (PR8 virus) results in the stimulation of maximal serum antibody titers, greatest numbers of antibody-forming cells (AFC), and strong virus-specific cytotoxic T lymphocyte (CTL) activity. In contrast, inoculation of formalin-inactivated virus, which induced antibody titers of equivalent magnitude, did not elicit a measurable primary CTL response nor prime for a secondary response. However, in mice previously exposed to untreated virus, challenge with formalin-inactivated virus evoked a secondary CTL response. Immunization of unprimed mice with aggregated viral glycoproteins or detergent-disrupted virus vaccine was much less immunogenic for antibody and AFC response and did not evoke measurable primary, secondary, or memory cytotoxic effector cells in vivo.
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M3 - Article
C2 - 7191866
AN - SCOPUS:0018969421
VL - 125
SP - 2182
EP - 2188
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 5
ER -