Abstract
Parenteral sensitization of mice with equivalent amounts of untreated, gradient-purified or UV-inactivated influenza A/PR/8/34 virus (PR8 virus) results in the stimulation of maximal serum antibody titers, greatest numbers of antibody-forming cells (AFC), and strong virus-specific cytotoxic T lymphocyte (CTL) activity. In contrast, inoculation of formalin-inactivated virus, which induced antibody titers of equivalent magnitude, did not elicit a measurable primary CTL response nor prime for a secondary response. However, in mice previously exposed to untreated virus, challenge with formalin-inactivated virus evoked a secondary CTL response. Immunization of unprimed mice with aggregated viral glycoproteins or detergent-disrupted virus vaccine was much less immunogenic for antibody and AFC response and did not evoke measurable primary, secondary, or memory cytotoxic effector cells in vivo.
Original language | English (US) |
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Pages (from-to) | 2182-2188 |
Number of pages | 7 |
Journal | Journal of Immunology |
Volume | 125 |
Issue number | 5 |
State | Published - 1980 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology