TY - JOUR
T1 - Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract
AU - Margolis, Kara Gross
AU - Gershon, Michael David
AU - Bogunovic, Milena
N1 - Publisher Copyright:
© 2016
PY - 2016/7/1
Y1 - 2016/7/1
N2 - The gastrointestinal (GI) tract is the largest immune organ; in vertebrates, it is the only organ whose function is controlled by its own intrinsic enteric nervous system (ENS), but it is additionally regulated by extrinsic (sympathetic and parasympathetic) innervation. The GI nervous and immune systems are highly integrated in their common goal, which is to unite digestive functions with protection from ingested environmental threats. This review discusses the physiological relevance of enteric neuroimmune integration by summarizing the current knowledge of evolutionary and developmental pathways, cellular organization, and molecular mechanisms of neuroimmune interactions in health and disease.
AB - The gastrointestinal (GI) tract is the largest immune organ; in vertebrates, it is the only organ whose function is controlled by its own intrinsic enteric nervous system (ENS), but it is additionally regulated by extrinsic (sympathetic and parasympathetic) innervation. The GI nervous and immune systems are highly integrated in their common goal, which is to unite digestive functions with protection from ingested environmental threats. This review discusses the physiological relevance of enteric neuroimmune integration by summarizing the current knowledge of evolutionary and developmental pathways, cellular organization, and molecular mechanisms of neuroimmune interactions in health and disease.
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U2 - 10.1016/j.it.2016.05.003
DO - 10.1016/j.it.2016.05.003
M3 - Review article
C2 - 27289177
AN - SCOPUS:84976435928
SN - 1471-4906
VL - 37
SP - 487
EP - 501
JO - Trends in Immunology
JF - Trends in Immunology
IS - 7
ER -