Abstract
The cellular uptake and localization properties of DNA binding N-methylpyrrole/N-methylimidazole polyamide dye conjugates in a variety of living ells have been examined by confocal laser scanning microscopy. With the exception of certain T-cell lines, polyamide dye conjugates localize mainly in the cytoplasm and not in the nucleus. Reagents such as methanol typically used to fix cells for microscopy significantly alter the cellular localization of these DNA-binding ligands.
Original language | English (US) |
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Pages (from-to) | 3313-3318 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 10 |
Issue number | 10 |
DOIs | |
State | Published - 2002 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry