Century-scale Methylome Stability in a Recently Diverged Arabidopsis thaliana Lineage

Jörg Hagmann, Claude Becker, Jonas Müller, Oliver Stegle, Rhonda C. Meyer, George Wang, Korbinian Schneeberger, Joffrey Fitz, Thomas Altmann, Joy Bergelson, Karsten Borgwardt, Detlef Weigel

Research output: Contribution to journalArticlepeer-review


There has been much excitement about the possibility that exposure to specific environments can induce an ecological memory in the form of whole-sale, genome-wide epigenetic changes that are maintained over many generations. In the model plant Arabidopsis thaliana, numerous heritable DNA methylation differences have been identified in greenhouse-grown isogenic lines, but it remains unknown how natural, highly variable environments affect the rate and spectrum of such changes. Here we present detailed methylome analyses in a geographically dispersed A. thaliana population that constitutes a collection of near-isogenic lines, diverged for at least a century from a common ancestor. Methylome variation largely reflected genetic distance, and was in many aspects similar to that of lines raised in uniform conditions. Thus, even when plants are grown in varying and diverse natural sites, genome-wide epigenetic variation accumulates mostly in a clock-like manner, and epigenetic divergence thus parallels the pattern of genome-wide DNA sequence divergence.

Original languageEnglish (US)
Article numbere1004920
JournalPLoS genetics
Issue number1
StatePublished - 2015

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research


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