CHAPTER 1: Supramolecular Approaches to Protein Recognition

Joseph W. Meisel, Andrew D. Hamilton

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter begins with an account of the early developments in protein chemistry and supramolecular chemistry. We have attempted to summarize the seminal achievements in each of these vast fields, highlighting how one has informed the other over the past century. We focus on the central topic of molecular recognition and noncovalent interactions. Classic examples of molecular recognition in Nature (as evidenced by X-ray crystallography) and the corresponding motifs developed by supramolecular chemists are described. Synthetic scaffolds that mimic peptide and protein structures are also presented in the context of interaction inhibitors. By bringing together these illustrious examples we hope to encourage new collaborations between supramolecular chemists and biomedical scientists.

Original languageEnglish (US)
Title of host publicationSupramolecular Protein Chemistry
Subtitle of host publicationAssembly, Architecture and Application
EditorsPeter B. Crowley
PublisherRoyal Society of Chemistry
Number of pages25
StatePublished - 2021

Publication series

NameMonographs in Supramolecular Chemistry
ISSN (Print)1368-8642
ISSN (Electronic)2041-7144

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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