Chapter 3 Transcriptional Control of Gene Expression by Actin and Myosin

Emilie Louvet, Piergiorgio Percipalle

Research output: Contribution to journalReview article

Abstract

Recent years have witnessed a new turn in the field of gene expression regulation. Actin and an ever-growing family of actin-associated proteins have been accepted as members of the nuclear crew, regulating eukaryotic gene transcription. In complex with heterogeneous nuclear ribonucleoproteins and certain myosin species, actin has been shown to be an important regulator in RNA polymerase II transcription. Furthermore, actin-based molecular motors are believed to facilitate RNA polymerase I transcription and possibly downstream events during rRNA biogenesis. Probably these findings represent the tip of the iceberg of a rapidly expanding area within the functional architecture of the cell nucleus. Further studies will contribute to clarify how actin mediates nuclear functions with a glance to cytoplasmic signalling. These discoveries have the potential to define novel regulatory networks required to control gene expression at multiple levels.

Original languageEnglish (US)
Pages (from-to)107-147
Number of pages41
JournalInternational Review of Cell and Molecular Biology
Volume272
Issue numberC
DOIs
StatePublished - 2008

Keywords

  • Chromatin regulation
  • Gene expression
  • Molecular motors
  • Nuclear actin
  • Nuclear myosin
  • Nuclear structure
  • Transcription
  • rRNA biogenesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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