TY - JOUR
T1 - Characterization of Cortisol Dysregulation in Fibromyalgia and Chronic Fatigue Syndromes
T2 - A State-Space Approach
AU - Pednekar, Divesh Deepak
AU - Amin, Md Rafiul
AU - Azgomi, Hamid Fekri
AU - Aschbacher, Kirstin
AU - Crofford, Leslie J.
AU - Faghih, Rose T.
N1 - Funding Information:
Manuscript received October 2, 2019; revised January 28, 2020; accepted February 26, 2020. Date of publication March 5, 2020; date of current version October 20, 2020. This work was supported in part by NSF under Grant 1755780 – CRII: CPS: Wearable-Machine Interface Architectures. This paper was presented in part at the Proceedings of the IEEE Engineering in Medicine and Biology Society Conference, Berlin, Germany, July 23–27, 2019. [1]. (Corresponding author: Rose T. Faghih.) Divesh Deepak Pednekar, Md. Rafiul Amin, and Hamid Fekri Azgomi are with the Department of Electrical and Computer Engineering, University of Houston.
Publisher Copyright:
© 1964-2012 IEEE.
PY - 2020/11
Y1 - 2020/11
N2 - Objective: Fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS) are complicated medical disorders, with little known etiologies. The purpose of this research is to characterize FMS and CFS by studying the variations in cortisol secretion patterns, timings, amplitudes, the number of underlying pulses, as well as infusion and clearance rates of cortisol. Methods: Using a physiological state-space model with plausible constraints, we estimate the hormonal secretory events and the physiological system parameters (i.e., infusion and clearance rates). Results: Our results show that the clearance rate of cortisol is lower in FMS patients as compared to their matched healthy individuals based on a simplified cortisol secretion model. Moreover, the number, magnitude, and energy of hormonal secretory events are lower in FMS patients. During early morning hours, the magnitude and energy of the hormonal secretory events are higher in CFS patients. Conclusion: Due to lower cortisol clearance rate, there is a higher accumulation of cortisol in FMS patients as compared to their matched healthy subjects. As the FMS patient accumulates higher cortisol residues, internal inhibitory feedback regulates the hormonal secretory events. Therefore, the FMS patients show a lower number, magnitude, and energy of hormonal secretory events. Though CFS patients have the same number of secretory events, they secrete lower quantities during early morning hours. When we compare the results for CFS patients against FMS patients, we observe different cortisol alteration patterns. Significance: Characterizing CFS and FMS based on the cortisol alteration will help us to develop novel methods for treating these disorders.
AB - Objective: Fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS) are complicated medical disorders, with little known etiologies. The purpose of this research is to characterize FMS and CFS by studying the variations in cortisol secretion patterns, timings, amplitudes, the number of underlying pulses, as well as infusion and clearance rates of cortisol. Methods: Using a physiological state-space model with plausible constraints, we estimate the hormonal secretory events and the physiological system parameters (i.e., infusion and clearance rates). Results: Our results show that the clearance rate of cortisol is lower in FMS patients as compared to their matched healthy individuals based on a simplified cortisol secretion model. Moreover, the number, magnitude, and energy of hormonal secretory events are lower in FMS patients. During early morning hours, the magnitude and energy of the hormonal secretory events are higher in CFS patients. Conclusion: Due to lower cortisol clearance rate, there is a higher accumulation of cortisol in FMS patients as compared to their matched healthy subjects. As the FMS patient accumulates higher cortisol residues, internal inhibitory feedback regulates the hormonal secretory events. Therefore, the FMS patients show a lower number, magnitude, and energy of hormonal secretory events. Though CFS patients have the same number of secretory events, they secrete lower quantities during early morning hours. When we compare the results for CFS patients against FMS patients, we observe different cortisol alteration patterns. Significance: Characterizing CFS and FMS based on the cortisol alteration will help us to develop novel methods for treating these disorders.
KW - Biomedical signal processing
KW - deconvolution
KW - state-space methods
KW - statistical analysis
KW - system identification
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U2 - 10.1109/TBME.2020.2978801
DO - 10.1109/TBME.2020.2978801
M3 - Article
C2 - 32149617
AN - SCOPUS:85093905383
SN - 0018-9294
VL - 67
SP - 3163
EP - 3172
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 11
M1 - 9025248
ER -