Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells

Maria Pokrovskii, Jason A. Hall, David E. Ochayon, Ren Yi, Natalia S. Chaimowitz, Harsha Seelamneni, Nicholas Carriero, Aaron Watters, Stephen N. Waggoner, Dan R. Littman, Richard Bonneau, Emily R. Miraldi

Research output: Contribution to journalArticlepeer-review

Abstract

Innate lymphoid cells contribute to tissue homeostasis and defense against pathogens, processes that require coordinated transcription of thousands of genes. Pokrovskii and colleagues construct and experimentally validate a genome-scale transcriptional regulatory network describing how intestinal ILC gene expression programs and their plasticity are controlled by transcription factors.

Original languageEnglish (US)
Pages (from-to)185-197.e6
JournalImmunity
Volume51
Issue number1
DOIs
StatePublished - Jul 16 2019

Keywords

  • ATAC-seq
  • Inferelator
  • gene regulation
  • lineage commitment
  • lymphocyte development

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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