Abstract
Innate lymphoid cells contribute to tissue homeostasis and defense against pathogens, processes that require coordinated transcription of thousands of genes. Pokrovskii and colleagues construct and experimentally validate a genome-scale transcriptional regulatory network describing how intestinal ILC gene expression programs and their plasticity are controlled by transcription factors.
Original language | English (US) |
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Pages (from-to) | 185-197.e6 |
Journal | Immunity |
Volume | 51 |
Issue number | 1 |
DOIs | |
State | Published - Jul 16 2019 |
Keywords
- ATAC-seq
- Inferelator
- gene regulation
- lineage commitment
- lymphocyte development
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases