Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells

Maria Pokrovskii; Jason A. Hall; David E. Ochayon; Ren Yi; Natalia S. Chaimowitz; Harsha Seelamneni; Nicholas Carriero; Aaron Watters; Stephen N. Waggoner; Dan R. Littman; Richard Bonneau; Emily R. Miraldi

doi:10.1016/j.immuni.2019.06.001

Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells

Maria Pokrovskii, Jason A. Hall, David E. Ochayon, Ren Yi, Natalia S. Chaimowitz, Harsha Seelamneni, Nicholas Carriero, Aaron Watters, Stephen N. Waggoner, Dan R. Littman, Richard Bonneau, Emily R. Miraldi

Research output: Contribution to journal › Article › peer-review

Abstract

Innate lymphoid cells contribute to tissue homeostasis and defense against pathogens, processes that require coordinated transcription of thousands of genes. Pokrovskii and colleagues construct and experimentally validate a genome-scale transcriptional regulatory network describing how intestinal ILC gene expression programs and their plasticity are controlled by transcription factors.

Original language	English (US)
Pages (from-to)	185-197.e6
Journal	Immunity
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2019.06.001
State	Published - Jul 16 2019

Keywords

ATAC-seq
Inferelator
gene regulation
lineage commitment
lymphocyte development

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/j.immuni.2019.06.001

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Pokrovskii, M., Hall, J. A., Ochayon, D. E., Yi, R., Chaimowitz, N. S., Seelamneni, H., Carriero, N., Watters, A., Waggoner, S. N., Littman, D. R., Bonneau, R., & Miraldi, E. R. (2019). Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells. Immunity, 51(1), 185-197.e6. https://doi.org/10.1016/j.immuni.2019.06.001

Pokrovskii, M, Hall, JA, Ochayon, DE, Yi, R, Chaimowitz, NS, Seelamneni, H, Carriero, N, Watters, A, Waggoner, SN, Littman, DR, Bonneau, R & Miraldi, ER 2019, 'Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells', Immunity, vol. 51, no. 1, pp. 185-197.e6. https://doi.org/10.1016/j.immuni.2019.06.001

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abstract = "Innate lymphoid cells contribute to tissue homeostasis and defense against pathogens, processes that require coordinated transcription of thousands of genes. Pokrovskii and colleagues construct and experimentally validate a genome-scale transcriptional regulatory network describing how intestinal ILC gene expression programs and their plasticity are controlled by transcription factors.",

keywords = "ATAC-seq, Inferelator, gene regulation, lineage commitment, lymphocyte development",

author = "Maria Pokrovskii and Hall, \{Jason A.\} and Ochayon, \{David E.\} and Ren Yi and Chaimowitz, \{Natalia S.\} and Harsha Seelamneni and Nicholas Carriero and Aaron Watters and Waggoner, \{Stephen N.\} and Littman, \{Dan R.\} and Richard Bonneau and Miraldi, \{Emily R.\}",

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year = "2019",

month = jul,

day = "16",

doi = "10.1016/j.immuni.2019.06.001",

language = "English (US)",

volume = "51",

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T1 - Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells

AU - Pokrovskii, Maria

AU - Hall, Jason A.

AU - Ochayon, David E.

AU - Yi, Ren

AU - Chaimowitz, Natalia S.

AU - Seelamneni, Harsha

AU - Carriero, Nicholas

AU - Watters, Aaron

AU - Waggoner, Stephen N.

AU - Littman, Dan R.

AU - Bonneau, Richard

AU - Miraldi, Emily R.

PY - 2019/7/16

Y1 - 2019/7/16

N2 - Innate lymphoid cells contribute to tissue homeostasis and defense against pathogens, processes that require coordinated transcription of thousands of genes. Pokrovskii and colleagues construct and experimentally validate a genome-scale transcriptional regulatory network describing how intestinal ILC gene expression programs and their plasticity are controlled by transcription factors.

AB - Innate lymphoid cells contribute to tissue homeostasis and defense against pathogens, processes that require coordinated transcription of thousands of genes. Pokrovskii and colleagues construct and experimentally validate a genome-scale transcriptional regulatory network describing how intestinal ILC gene expression programs and their plasticity are controlled by transcription factors.

KW - ATAC-seq

KW - Inferelator

KW - gene regulation

KW - lineage commitment

KW - lymphocyte development

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Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells

Abstract

Keywords

ASJC Scopus subject areas

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