Characterizing infantile hemangiomas with a near-infrared spectroscopic handheld wireless device

Christopher J. Fong, Jennifer W. Hoi, Hyun K. Kim, Gerald Behr, Lauren Geller, Nina Antonov, Molly Flexman, Maria Garzon, Andreas H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Infantile hemangiomas (IH) are common vascular growths that occur in 5-10% of neonates and have the potential to cause disfiguring and even life-threatening complications. Currently, no objective tool exist to monitor either progression or treatment of IH. To address this unmet clinical need, we have developed a handheld wireless device (HWD) that uses diffuse optical spectroscopy for the assessment of IH. The system employs 4 wavelengths (l=780nm, 805nm, 850nm, and 905nm) and 6 source-detector pairs with distances between 0.6 and 20 mm. Placed on the skin surface, backreflection data is obtained and a multispectral evolution algorithm is used to determine total hemoglobin concentration and tissue oxygen saturation. First results of an ongoing pilot study involving 13 patients (average enrollment age = 25 months) suggest that an increase in hypoxic stress over time can lead to the proliferation of IH. Involuting IH lesions showed an increase in tissue oxygen saturation as well as a decrease in total hemoglobin.

Original languageEnglish (US)
Title of host publicationOptical Tomography and Spectroscopy of Tissue XI
EditorsRobert R. Alfano, Eva M. Sevick-Muraca, Bruce J. Tromberg, Arjun G. Yodh
PublisherSPIE
ISBN (Electronic)9781628414097
DOIs
StatePublished - 2015
EventOptical Tomography and Spectroscopy of Tissue XI - San Francisco, United States
Duration: Feb 9 2015Feb 11 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9319
ISSN (Print)1605-7422

Conference

ConferenceOptical Tomography and Spectroscopy of Tissue XI
Country/TerritoryUnited States
CitySan Francisco
Period2/9/152/11/15

Keywords

  • diffuse optical spectroscopy
  • handheld
  • hemangiomas
  • wireless

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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