@inproceedings{d84c6e40844b48ce87f6c8f502f89862,
title = "Characterizing infantile hemangiomas with a near-infrared spectroscopic handheld wireless device",
abstract = "Infantile hemangiomas (IH) are common vascular growths that occur in 5-10% of neonates and have the potential to cause disfiguring and even life-threatening complications. Currently, no objective tool exist to monitor either progression or treatment of IH. To address this unmet clinical need, we have developed a handheld wireless device (HWD) that uses diffuse optical spectroscopy for the assessment of IH. The system employs 4 wavelengths (l=780nm, 805nm, 850nm, and 905nm) and 6 source-detector pairs with distances between 0.6 and 20 mm. Placed on the skin surface, backreflection data is obtained and a multispectral evolution algorithm is used to determine total hemoglobin concentration and tissue oxygen saturation. First results of an ongoing pilot study involving 13 patients (average enrollment age = 25 months) suggest that an increase in hypoxic stress over time can lead to the proliferation of IH. Involuting IH lesions showed an increase in tissue oxygen saturation as well as a decrease in total hemoglobin.",
keywords = "diffuse optical spectroscopy, handheld, hemangiomas, wireless",
author = "Fong, {Christopher J.} and Hoi, {Jennifer W.} and Kim, {Hyun K.} and Gerald Behr and Lauren Geller and Nina Antonov and Molly Flexman and Maria Garzon and Hielscher, {Andreas H.}",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Optical Tomography and Spectroscopy of Tissue XI ; Conference date: 09-02-2015 Through 11-02-2015",
year = "2015",
doi = "10.1117/12.2079710",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Alfano, {Robert R.} and Sevick-Muraca, {Eva M.} and Tromberg, {Bruce J.} and Yodh, {Arjun G.}",
booktitle = "Optical Tomography and Spectroscopy of Tissue XI",
}