@article{61713a046ffb4bdeaeef043b125551f0,
title = "Charting the landscape of priority problems in psychiatry, part 1: Classification and diagnosis",
abstract = "Contemporary psychiatry faces major challenges. Its syndrome-based disease classification is not based on mechanisms and does not guide treatment, which largely depends on trial and error. The development of therapies is hindered by ignorance of potential beneficiary patient subgroups. Neuroscientific and genetics research have yet to affect disease definitions or contribute to clinical decision making. In this challenging setting, what should psychiatric research focus on? In two companion papers, we present a list of problems nominated by clinicians and researchers from different disciplines as candidates for future scientific investigation of mental disorders. These problems are loosely grouped into challenges concerning nosology and diagnosis (this Personal View) and problems related to pathogenesis and aetiology (in the companion Personal View). Motivated by successful examples in other disciplines, particularly the list of Hilbert's problems in mathematics, this subjective and eclectic list of priority problems is intended for psychiatric researchers, helping to re-focus existing research and providing perspectives for future psychiatric science.",
author = "Stephan, {Klaas E.} and Bach, {Dominik R.} and Fletcher, {Paul C.} and Jonathan Flint and Frank, {Michael J.} and Friston, {Karl J.} and Andreas Heinz and Huys, {Quentin J.M.} and Owen, {Michael J.} and Binder, {Elisabeth B.} and Peter Dayan and Johnstone, {Eve C.} and Andreas Meyer-Lindenberg and Montague, {P. Read} and Ulrich Schnyder and Wang, {Xiao Jing} and Michael Breakspear",
note = "Funding Information: We acknowledge funding from the following institutions: National Health and Medical Research Council (program grant 1037196 to MB), Wellcome Trust (to JF, KJF; and strategic award 503147 to MJO), Deutsche Forschungsgemeinschaft (DFG FOR 1617 to AH), Medical Research Council (Centre Grant G0800509 and Programme Grant G0801418 to MJO), Gatsby Charitable Foundation (to PD), German Ministry of Research and Education (to AM-L), EU Horizon 2020 (to AM-L), EU FP7 (to EBB and AM-L), ERC grant “GxE molmech”, grant 281338 (to EBB), Innovative Medicine Initiative program (to AM-L), Prix Robert de Spoelberch (to AM-L), National Institutes of Health (grant R01MH062349 to X-JW), Offi ce of Naval Research (grant N00014–13–1-0297 to X-JW), NHMRC program grant APP1037196 (to MB), the Ren{\'e} and Susanne Braginsky Foundation (to KES), and University of Zurich (to KES). The funding sources had no role in the writing of the manuscript or the decision to submit it for publication. Funding Information: We acknowledge funding from the following institutions: National Health and Medical Research Council (program grant 1037196 to MB), Wellcome Trust (to JF, KJF; and strategic award 503147 to MJO), Deutsche Forschungsgemeinschaft (DFG FOR 1617 to AH), Medical Research Council (Centre Grant G0800509 and Programme Grant G0801418 to MJO), Gatsby Charitable Foundation (to PD), German Ministry of Research and Education (to AM-L), EU Horizon 2020 (to AM-L), EU FP7 (to EBB and AM-L), ERC grant “GxE molmech”, grant 281338 (to EBB), Innovative Medicine Initiative program (to AM-L), Prix Robert de Spoelberch (to AM-L), National Institutes of Health (grant R01MH062349 to X-JW), Office of Naval Research (grant N00014–13–1-0297 to X-JW), NHMRC program grant APP1037196 (to MB), the Ren{\'e} and Susanne Braginsky Foundation (to KES), and University of Zurich (to KES). The funding sources had no role in the writing of the manuscript or the decision to submit it for publication. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",
year = "2016",
month = jan,
day = "1",
doi = "10.1016/S2215-0366(15)00361-2",
language = "English (US)",
volume = "3",
pages = "77--83",
journal = "The Lancet Psychiatry",
issn = "2215-0366",
publisher = "Elsevier Limited",
number = "1",
}