TY - JOUR
T1 - Checkpoint mechanisms
T2 - The puppet masters of meiotic prophase
AU - MacQueen, Amy J.
AU - Hochwagen, Andreas
PY - 2011/7
Y1 - 2011/7
N2 - The coordinated execution of cell cycle processes during meiosis is essential for the production of viable gametes and fertility. Coordination is particularly important during meiotic prophase, when nuclei undergo a dramatic reorganization that requires the precise choreography of chromosome movements, pairing interactions and DNA double-strand break (DSB) repair. Analysis of the underlying regulatory mechanisms has revealed crucial and widespread roles for DNA-damage checkpoint proteins, not only in cell cycle surveillance, but also in controlling many processes uniquely characteristic of meiosis. The resulting regulatory network uses checkpoint machinery to provide an integral coordinating mechanism during every meiotic division and enables cells to safely maintain an error-prone event such as DSB formation as an essential part of the meiotic program.
AB - The coordinated execution of cell cycle processes during meiosis is essential for the production of viable gametes and fertility. Coordination is particularly important during meiotic prophase, when nuclei undergo a dramatic reorganization that requires the precise choreography of chromosome movements, pairing interactions and DNA double-strand break (DSB) repair. Analysis of the underlying regulatory mechanisms has revealed crucial and widespread roles for DNA-damage checkpoint proteins, not only in cell cycle surveillance, but also in controlling many processes uniquely characteristic of meiosis. The resulting regulatory network uses checkpoint machinery to provide an integral coordinating mechanism during every meiotic division and enables cells to safely maintain an error-prone event such as DSB formation as an essential part of the meiotic program.
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U2 - 10.1016/j.tcb.2011.03.004
DO - 10.1016/j.tcb.2011.03.004
M3 - Review article
C2 - 21531561
AN - SCOPUS:79959610377
SN - 0962-8924
VL - 21
SP - 393
EP - 400
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 7
ER -