Chemical exchange saturation transfer by intermolecular double-quantum coherence

Wen Ling, Uzi Eliav, Gil Navon, Alexej Jerschow

Research output: Contribution to journalArticle

Abstract

A number of contrast enhancement effects based on the use of intermolecular multiple-quantum coherences, or distant dipolar field effects are known. This phenomenon is characterized by the dependence on the mth power of the initial magnetization (where m is the coherence order used). In this paper, we describe the contrast enhancement based on chemical exchange saturation transfer and NOE, which is achieved by the use of intermolecular double-quantum coherences (iDQC). The method was validated using clinically relevant systems based on glycosaminoglycans and a sample of cartilage tissue, showing that the CEST contrast, as well as, NOE are enhanced by iDQC.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalJournal of Magnetic Resonance
Volume194
Issue number1
DOIs
StatePublished - Sep 2008

Keywords

  • CEST
  • Chemical exchange saturation transfer
  • DDF
  • Distant dipolar field
  • Intermolecular multiple-quantum coherences
  • MRI
  • Nonlinear dynamics
  • iMQC

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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