Cholera and shigellosis: Different epidemiology but similar responses to climate variability

Benjamin A. Cash, Xavier Rodo, Michael Emch, M. D. Yunus, Abu S.G. Faruque, Mercedes Pascual

Research output: Contribution to journalArticlepeer-review


Background: Comparative studies of the associations between different infectious diseases and climate variability, such as the El Nin" o-Southern Oscillation, are lacking. Diarrheal illnesses, particularly cholera and shigellosis, provide an important opportunity to apply a comparative approach. Cholera and shigellosis have significant global mortality and morbidity burden, pronounced differences in transmission pathways and pathogen ecologies, and there is an established climate link with cholera. In particular, the specific ecology of Vibrio cholerae is often invoked to explain the sensitivity of that disease to climate.

Methods and Findings: The extensive surveillance data of the International Center for Diarrheal Disease Research, Bangladesh are used here to revisit the known associations between cholera and climate, and to address their similarity to previously unexplored patterns for shigellosis. Monthly case data for both the city of Dhaka and a rural area known as Matlab are analyzed with respect to their association with El Nin"o and flooding. Linear correlations are examined between flooding and cumulative cases, as well as for flooding and El Nin" o. Rank-correlation maps are also computed between disease cases in the post-monsoon epidemic season and sea surface temperatures in the Pacific. Similar climate associations are found for both diseases and both locations. Increased cases follow increased monsoon flooding and increased sea surface temperatures in the preceding winter corresponding to an El Nin"o event.

Conclusions: The similarity in association patterns suggests a systemic breakdown in population health with changing environmental conditions, in which climate variability acts primarily through increasing the exposure risk of the human population. We discuss these results in the context of the on-going debate on the relative importance of the environmental reservoir vs. secondary transmission, as well as the implications for the use of El Nin"o as an early indicator of flooding and enteric disease risk.

Original languageEnglish (US)
Article numberA1306
JournalPloS one
Issue number9
StatePublished - Sep 17 2014

ASJC Scopus subject areas

  • General


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