Chondrocyte Maturation on Biphasic Calcium Phosphate Scaffold: A Preliminary Study

Cristina C. Teixeira, Racquel Z. LeGeros, Claudia Karkia, Yelena Nemelivsky

Research output: Contribution to journalConference articlepeer-review


An in vitro cartilage template was created that, after implantation in vivo, remodels into bone. The aim of the study was to establish a method of growing chondrocytes in a well characterized biphasic calcium phosphate (BCP) scaffold. The study also aimed at inducing chondrocytes hypertrophy and cartilage matrix deposition in cells growing in the BCP scaffold. Scanning electron microscopy was used to observe chondrocyte proliferation. Spectrophotometry was used to measure alkaline phosphatase (AP) activity.

Original languageEnglish (US)
Pages (from-to)817-820
Number of pages4
JournalKey Engineering Materials
StatePublished - 2004
EventThe Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal
Duration: Nov 6 2003Nov 9 2003


  • Alkaline phosphatase
  • Biphasic calcium phosphate
  • Chondrocytes
  • Collagen
  • Maturation

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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