Chromatin dynamics at the replication fork: There's more to life than histones

Iestyn Whitehouse; Duncan J. Smith

doi:10.1016/j.gde.2012.12.007

Chromatin dynamics at the replication fork: There's more to life than histones

Iestyn Whitehouse, Duncan J. Smith

Biology and Genomics

Research output: Contribution to journal › Review article › peer-review

Abstract

Before each division, eukaryotic cells face the daunting task of completely and accurately replicating a heterogeneous, chromatinized genome and repackaging both resulting daughters. Because replication requires strand separation, interactions between the DNA and its many associated proteins - including histones - must be transiently broken to allow the passage of the replication fork. Here, we will discuss the disruption and re-establishment of chromatin structure during replication, and the consequences of these processes for epigenetic inheritance.

Original language	English (US)
Pages (from-to)	140-146
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/j.gde.2012.12.007
State	Published - Apr 2013

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/j.gde.2012.12.007

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title = "Chromatin dynamics at the replication fork: There's more to life than histones",

abstract = "Before each division, eukaryotic cells face the daunting task of completely and accurately replicating a heterogeneous, chromatinized genome and repackaging both resulting daughters. Because replication requires strand separation, interactions between the DNA and its many associated proteins - including histones - must be transiently broken to allow the passage of the replication fork. Here, we will discuss the disruption and re-establishment of chromatin structure during replication, and the consequences of these processes for epigenetic inheritance.",

author = "Iestyn Whitehouse and Smith, {Duncan J.}",

note = "Funding Information: We have highlighted only papers published in the past three years and apologize to colleagues whose work could not be cited due to space limitations. This work was supported by National Institute of Health Grant R01 GM102253 and an Alfred Bressler Scholars Endowment Award to I.W.; D.J.S. is a HHMI fellow of the Damon Runyon Cancer Research Foundation ( DRG-#2046-10 ).",

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N1 - Funding Information: We have highlighted only papers published in the past three years and apologize to colleagues whose work could not be cited due to space limitations. This work was supported by National Institute of Health Grant R01 GM102253 and an Alfred Bressler Scholars Endowment Award to I.W.; D.J.S. is a HHMI fellow of the Damon Runyon Cancer Research Foundation ( DRG-#2046-10 ).

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N2 - Before each division, eukaryotic cells face the daunting task of completely and accurately replicating a heterogeneous, chromatinized genome and repackaging both resulting daughters. Because replication requires strand separation, interactions between the DNA and its many associated proteins - including histones - must be transiently broken to allow the passage of the replication fork. Here, we will discuss the disruption and re-establishment of chromatin structure during replication, and the consequences of these processes for epigenetic inheritance.

AB - Before each division, eukaryotic cells face the daunting task of completely and accurately replicating a heterogeneous, chromatinized genome and repackaging both resulting daughters. Because replication requires strand separation, interactions between the DNA and its many associated proteins - including histones - must be transiently broken to allow the passage of the replication fork. Here, we will discuss the disruption and re-establishment of chromatin structure during replication, and the consequences of these processes for epigenetic inheritance.

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Chromatin dynamics at the replication fork: There's more to life than histones

Abstract

ASJC Scopus subject areas

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