Chromatin dynamics at the replication fork: There's more to life than histones

Iestyn Whitehouse, Duncan J. Smith

Research output: Contribution to journalReview articlepeer-review

Abstract

Before each division, eukaryotic cells face the daunting task of completely and accurately replicating a heterogeneous, chromatinized genome and repackaging both resulting daughters. Because replication requires strand separation, interactions between the DNA and its many associated proteins - including histones - must be transiently broken to allow the passage of the replication fork. Here, we will discuss the disruption and re-establishment of chromatin structure during replication, and the consequences of these processes for epigenetic inheritance.

Original languageEnglish (US)
Pages (from-to)140-146
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume23
Issue number2
DOIs
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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