TY - JOUR
T1 - Chromatin remodelling and transcription
T2 - be-WICHed by nuclear myosin 1
AU - Percipalle, Piergiorgio
AU - Farrants, Ann Kristin Östlund
N1 - Funding Information:
Our work is funded by grants from the Swedish Research Council (Vetenskapsrådet). We would like to thank George Farrants for language editing.
PY - 2006/6
Y1 - 2006/6
N2 - Transcription in eukaryotic cells requires dynamic changes of chromatin structure to facilitate or prevent RNA polymerase access to active genes. These structural modifications rely on the concerted action of ATP-dependent chromatin-remodelling complexes and histone-modifying enzymes, which generate a chromatin configuration that is either compatible with transcription (euchromatin) or incompatible (heterochromatin). Insights into how these structural changes might be coordinated for RNA polymerase I (pol I) genes come from the discoveries of the nucleolar-remodelling complex (NoRC) and B-WICH - a high molecular weight fraction of the WSTF/SNF2h chromatin-remodelling complex. NoRC produces a repressive chromatin state; B-WICH, together with nuclear myosin 1, activates pol I transcription directly on chromatin templates and might also function in the maintenance of ribosomal chromatin structure.
AB - Transcription in eukaryotic cells requires dynamic changes of chromatin structure to facilitate or prevent RNA polymerase access to active genes. These structural modifications rely on the concerted action of ATP-dependent chromatin-remodelling complexes and histone-modifying enzymes, which generate a chromatin configuration that is either compatible with transcription (euchromatin) or incompatible (heterochromatin). Insights into how these structural changes might be coordinated for RNA polymerase I (pol I) genes come from the discoveries of the nucleolar-remodelling complex (NoRC) and B-WICH - a high molecular weight fraction of the WSTF/SNF2h chromatin-remodelling complex. NoRC produces a repressive chromatin state; B-WICH, together with nuclear myosin 1, activates pol I transcription directly on chromatin templates and might also function in the maintenance of ribosomal chromatin structure.
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U2 - 10.1016/j.ceb.2006.03.001
DO - 10.1016/j.ceb.2006.03.001
M3 - Review article
C2 - 16574391
AN - SCOPUS:33746279691
SN - 0955-0674
VL - 18
SP - 267
EP - 274
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -