Chromatin remodelling and transcription: be-WICHed by nuclear myosin 1

Piergiorgio Percipalle, Ann Kristin Östlund Farrants

Research output: Contribution to journalReview article

Abstract

Transcription in eukaryotic cells requires dynamic changes of chromatin structure to facilitate or prevent RNA polymerase access to active genes. These structural modifications rely on the concerted action of ATP-dependent chromatin-remodelling complexes and histone-modifying enzymes, which generate a chromatin configuration that is either compatible with transcription (euchromatin) or incompatible (heterochromatin). Insights into how these structural changes might be coordinated for RNA polymerase I (pol I) genes come from the discoveries of the nucleolar-remodelling complex (NoRC) and B-WICH - a high molecular weight fraction of the WSTF/SNF2h chromatin-remodelling complex. NoRC produces a repressive chromatin state; B-WICH, together with nuclear myosin 1, activates pol I transcription directly on chromatin templates and might also function in the maintenance of ribosomal chromatin structure.

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume18
Issue number3
DOIs
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Cell Biology

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