Abstract
In this paper we report the cloning, sequence and expression analysis of a new Ciona intestinalis hox gene. On the basis of sequence comparison with mammalian and Amphioxus homologues, we called this gene Cihox5. Northern blot analysis reveals a single transcript of about 1.3 kb in length, that is present from neurula until larva stage. Whole-mount in situ hybridization shows restricted expression of this gene in putative blood cells precursors and in a regional domain of the spinal chord. Expression in the spinal cord is attributed to ependymal cells. This result implies a role for this gene in primitive regionalization of spinal cord along the anteroposterior axis in the absence of neuronal bodies.
Original language | English (US) |
---|---|
Pages (from-to) | 515-523 |
Number of pages | 9 |
Journal | Development Genes and Evolution |
Volume | 207 |
Issue number | 8 |
DOIs | |
State | Published - 1998 |
Keywords
- Ascidians
- CNS regionalization
- Hox
- Neural tube
ASJC Scopus subject areas
- Genetics
- Developmental Biology