Cinnamate-based DNA photolithography

Lang Feng, Joy Romulus, Minfeng Li, Ruojie Sha, John Royer, Kun Ta Wu, Qin Xu, Nadrian C. Seeman, Marcus Weck, Paul Chaikin

Research output: Contribution to journalArticlepeer-review


As demonstrated by means of DNA nanoconstructs, as well as DNA functionalization of nanoparticles and micrometre-scale colloids, complex self-assembly processes require components to associate with particular partners in a programmable fashion. In many cases the reversibility of the interactions between complementary DNA sequences is an advantage. However, permanently bonding some or all of the complementary pairs may allow for flexibility in design and construction. Here, we show that the substitution of a cinnamate group for a pair of complementary bases provides an efficient, addressable, ultraviolet light-based method to bond complementary DNA covalently. To show the potential of this approach, we wrote micrometre-scale patterns on a surface using ultraviolet light and demonstrated the reversible attachment of conjugated DNA and DNA-coated colloids. Our strategy enables both functional DNA photolithography and multistep, specific binding in self-assembly processes.

Original languageEnglish (US)
Pages (from-to)747-753
Number of pages7
JournalNature Materials
Issue number8
StatePublished - Aug 2013

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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