Circuit organization of the rodent medial prefrontal cortex

Paul G. Anastasiades, Adam G. Carter

Research output: Contribution to journalReview articlepeer-review


The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous variety of projection neurons and interneurons. These cells are engaged by long-range inputs from other brain regions involved in cognition, motivation, and emotion. They also communicate in the local network via specific connections between excitatory and inhibitory cells. In this review, we describe the cellular diversity of the rodent mPFC, the impact of long-range afferents, and the specificity of local microcircuits. We highlight similarities with and differences between other cortical areas, illustrating how the circuit organization of the mPFC may give rise to its unique functional roles.

Original languageEnglish (US)
Pages (from-to)550-563
Number of pages14
JournalTrends in Neurosciences
Issue number7
StatePublished - Jul 2021


  • cell types
  • circuits
  • interneuron
  • prefrontal cortex
  • projection neuron
  • synapses

ASJC Scopus subject areas

  • General Neuroscience


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